Abstract:Background
The Human Leucocyte Antigen/Major Histocompatibility Complex (HLA/MHC) locus is highly complex, with very many genetic variants, extensive linkage disequilibrium blocks, population-specific linkage disequilibrium patterns and many genes. So, whilst many traits have been associated with the HLA/MHC locus, it has largely been omitted from post-genome-wide association study analyses.
Methods
Here we used the UK Biobank cohort to explore the genetic architecture of the HLA/MHC locus in severe mental i… Show more
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