Genetic and Physical Mapping of the Bovine X Chromosome

Yeh, C. C.; Taylor, Jeremy F.; Gallagher, D. S.; Sanders, James O.; Turner, James; Davis, Scott K.

doi:10.1006/geno.1996.0111

Cited by 24 publications

(27 citation statements)

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“…The linkage distances (Kosambi cM) between these markers in both species are almost identical, indicating that the two chromosomes are not rearranged with respect to each other over the regions common to both. The cattle X chromosome map is -20 cM shorter than our sheep map, and this fits with the observation of Yeh et al (1996) that their linkage map was -30-50 cM shorter that the predicted physical length.MAF45 is pseudoautosomal in cattle as it is in sheep. Comparison of the banding patterns and genetic linkage maps of sheep and cattle autosomes shows considerable homology, and the difference in chromosome number can be explained by centromeric fusions of smaller cattle chromosomes (Hediger et al 1991;Echard et al 1994;Crawford et al 1995).…”

supporting

confidence: 87%

“…Mapping data is from sheep (this study), cattle (Echard et al 1994), mouse (Herman et al 1994, and human gene locations from the GDB Human Genome Data Base (Johns Hopkins University, Baltimore, MD) on July 18, 1995 at 3:54 pm Eastern time. The position of the cattle pseudoautosomal region is from Yeh et al (1996).Cold Spring Harbor Laboratory Press on May 8, 2018 -Published by genome.cshlp.org Downloaded from OVINE X CHROMOSOME MAP(type I) allows comparison of this map with hum a n and mouse X chromosome maps. All seven gene markers reported here have m a p p e d homologs in humans, and all but TBG have mapped homologs in mice.…”

mentioning

confidence: 99%

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A linkage map of the ovine X chromosome.

Galloway

Hanrahan²,

Dodds³

et al. 1996

Genome Res.

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A genetic linkage map of the ovine X chromosome containing type I and type II markers has been constructed. The map contains 7 known gene markers and 14 microsatellite markers with a recombination length of 141.9 cM. Segregation of polymorphic markers was observed in a three-generation pedigree containing 480 animals. The maximum number of informative meioses was 912. Additional information was obtained for some markers by following segregation in the AgResearch International Mapping Flock, consisting of nine three-generation full-sib pedigrees. A pseudoautosomal region containing two markers has been identified at one end of the linkage map. Comparisons with mouse and human X chromosomes confirms the observation of Ohno (1973} that the gene content of the mammalian X chromosome is retained. In particular, the conserved grouping of the genes PHKA1, ATP7A, and XIST observed in both the human and the mouse X chromosome appears to be conserved in the sheep X chromosome, and XIST has been mapped to near the center of the chromosome. This study provides the first reported genetic linkage map combining both type I and type 11 markers for any ruminant X chromosome.Until very recently, the X chromosomes of placental mammals were considered to be constrained by Ohno's rule (Ohno 1973), which postulated that genes on the X chromosome of one mammal would be on the X chromosomes of all other mammals. This rule was refined with the discovery that several genes on the short arm of the human X chromosome (Xp) are autosomal in marsupials and monotremes (McKay et al. 1992;Fitzgerald et al. 1993;Graves and Foster 1994). The apparent conservation of gene content of the X chromosomes was thought to be related to the requirement of X-inactivation in females for dosage compensation. The only known exception to this conservation in placental mammals has been a chloride channel gene (CLCN4), which has been shown recently to map to the X chromosome in humans and Mus spretus mice, but to chromosome 7 in C57BL/6 mice (Palmer et al. 1995;Rugarli et al. 1995). The X chromosomes of humans and mice are the most well-characterized and many known X-linked genes and other unique DNA sequences have been mapped in these species (Herman et al. 1994;Willard et al. 1994). Based on mapped gene orders, evolutionary relationships between mice and human X 3Corresponding author. E-MAIL galloways@agresearch.cri.nz; FAX 64-3-477-5413. chromosomes have been explained by five breakpoints and rearrangement of the resulting six blocks of genes (Amar et al. 1988). This concept has been refined recently to accommodate eight conserved segments with seven breakpoints (Blair et al. 1994(Blair et al. , 1995. It is of interest to determine whether the conserved blocks of genes identified in humans and mice remain conserved in other mammalian species, and whether the conservation of these groups has been maintained throughout evolution.The X chromosomes of mammalian species other than human and mouse are less wellcharacterized. In cattle, the genes DMD (Duchenne muscul...

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supporting

confidence: 87%

mentioning

confidence: 99%

A linkage map of the ovine X chromosome.

Galloway

Hanrahan²,

Dodds³

et al. 1996

Genome Res.

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“…Loci which appeared to be linked near the telomeres and centromere of BTX were selected for physical assignment. We report an increase in marker density for BTX almost fourfold higher than previously reported (Ponce de Le6n et al 1996;Yeh et al 1996), construction of a male-specific linkage map, and four physical assignments of BTXlinked loci that confirmed coverage. These results offer a comprehensive map of BTX that will ultimately enhance QTL analysis of this chromosome.…”

Section: Introductionsupporting

confidence: 51%

“…In constrast, fluorescent in situ hybridization (FISH) with a bovine Y Chr specific paint suggested the bovine PAR was located at Xq4 (Ponce de Le6n and Carpio 1995). This reorientation of the PAR was subsequently supported by assignment of INRA030 to Xq42-ter, a heterozygous locus closely linked to TGLA325 on the two most recent linkage maps of BTX (Ponce de Le6n et al 1996;Yeh et al 1996). The human and bovine X Chr are estimated at approximately 150 cM (Hamden and Klinger 1985).…”

Section: Introductionmentioning

confidence: 88%

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An integrated genetic and physical map of the bovine X Chromosome

Sonstegard¹,

Lopez-Corrales²,

Kappes³

et al. 1997

Mammalian Genome

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Abstract. Genotypic data for 56 microsatellites (ms) generated from maternal full sib families nested within paternal half sib pedigrees were used to construct a linkage map of the bovine X Chromosome (Chr) (BTX) that spans 150 cM (ave. interval 2.7 cM). The linkage map contains 36 previously unlinked ms; seven generated from a BTXp library. Genotypic data from these 36 ms was merged into an existing linkage map to more than double the number of informative BTX markers. A male specific linkage map of the pseudoautosomal region was also constructed from five ms at the distal end of BTXq. Four informative probes physically assigned by fluorescence in situ hybridization defined the extent of coverage, confirmed the position of the pseudoautosomal region on the q-arm, and identified a 4.1-cM marker interval containing the centromere of BTX.

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History of Linkage Mapping the Bovine Genome

McKay

Schnabel

2012

Bovine Genomics

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Genetic and Physical Mapping of the Bovine X Chromosome

Cited by 24 publications

References 0 publications

A linkage map of the ovine X chromosome.

A linkage map of the ovine X chromosome.

An integrated genetic and physical map of the bovine X Chromosome

History of Linkage Mapping the Bovine Genome

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