Genetic and Phenotypic Diversity of <i>Listeria monocytogenes</i> in Pig Slaughterhouses in Korea

Hong, Serim; Moon, Jin-San; Yoon, Soon-Seek; Kim, Ha-Young; Lee, Young Ju

doi:10.1089/fpd.2023.0053

Foodborne Pathogens and Disease

2024

DOI: 10.1089/fpd.2023.0053

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Genetic and Phenotypic Diversity of Listeria monocytogenes in Pig Slaughterhouses in Korea

Serim Hong,

Jin-San Moon,

Soon-Seek Yoon

et al.

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2024

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EⅡB Mutation Reduces the Pathogenicity of Listeria monocytogenes by Negatively Regulating Biofilm Formation Ability, Infective Capacity, and Virulence Gene Expression

Liu,

Qian,

Shi

et al. 2024

Veterinary Sciences

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To explore the role of the membrane permease ⅡB (EⅡB) gene of Listeria pathogenicity island 4 (LIPI-4) in the virulence of Listeria monocytogenes, both an EⅡB deletion strain (∆EⅡB) and a complemented strain were constructed. In vitro experiments demonstrated that EⅡB deletion affected the biofilm formation ability of the wild-type strain (Lm928). Moreover, this deletion decreased the intracellular proliferation abilities of L. monocytogenes. Mice infected with ∆EⅡB survived longer and experienced less weight loss on days 1, 2, and 3 post-infection. The bacterial load in the liver tissue of ∆EⅡB-infected mice was significantly reduced, and a considerable decrease in the blood levels of inflammatory cytokines IL-β, IL-6, IL-10, and TNF-α were observed. Following EⅡB deletion, 65% (13/20) of genes were downregulated, 25% (5/20) were upregulated, and 10% (2/20) showed no change. These findings suggest that EⅡB deletion may reduce both the in vivo and in vitro virulence levels as well as the biofilm formation ability of Lm928 by downregulating the transcription levels of genes associated with virulence and biofilm formation. These findings provide a foundation for further examining the pathogenic mechanisms of LIPI-4 and EⅡB in L. monocytogenes.

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EⅡB Mutation Reduces the Pathogenicity of Listeria monocytogenes by Negatively Regulating Biofilm Formation Ability, Infective Capacity, and Virulence Gene Expression

Liu,

Qian,

Shi

et al. 2024

Veterinary Sciences

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Genetic and Phenotypic Diversity of Listeria monocytogenes in Pig Slaughterhouses in Korea

Cited by 1 publication

References 54 publications

EⅡB Mutation Reduces the Pathogenicity of Listeria monocytogenes by Negatively Regulating Biofilm Formation Ability, Infective Capacity, and Virulence Gene Expression

EⅡB Mutation Reduces the Pathogenicity of Listeria monocytogenes by Negatively Regulating Biofilm Formation Ability, Infective Capacity, and Virulence Gene Expression

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