Genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors (GAPP)

Conen, David; Schön, Tobias; Aeschbacher, Stefanie; Paré, Guillaume; Frehner, Walter; Risch, Martin; Risch, Lorenz

doi:10.4414/smw.2013.13728

Cited by 30 publications

(82 citation statements)

References 44 publications

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“…The study methodology has been described in detail previously. 9 In brief, between 2010 and 2013, 2170 participants have been enrolled into GAPP. Main exclusion criteria are prevalent cardiovascular disease, a body mass index ≥35 kg/m 2 , and current intake of antidiabetic drugs.…”

Section: Methodsmentioning

confidence: 99%

Age-Specific Differences Between Conventional and Ambulatory Daytime Blood Pressure Values

et al. 2014

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Section: Methodsmentioning

confidence: 99%

Age-Specific Differences Between Conventional and Ambulatory Daytime Blood Pressure Values

et al. 2014

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“…Conventional BP assessment was performed after 5 minutes of rest with 3 consecutive BP measurements using a validated oscillometric device (Microlife BP3AG1; Microlife AG, Switzerland). 28 The mean of the second and third reading was used for our analysis.…”

Section: Bp Assessmentmentioning

confidence: 99%

“…28 BP measurements were performed every 15 minutes from 07:30 to 22:00 and every 30 minutes in the remaining time period. Individual diaries were used to define awake and asleep BP values.…”

Section: Bp Assessmentmentioning

confidence: 99%

“…Body composition was assessed by bioelectrical impedance analysis using a validated device (BIA ego fit, 2010, Germany). 28 Smoking status was graded as current, past, or never by self-assessment of the participants. Weight and height were directly measured in a standardized manner.…”

Section: Assessment Of Other Study Variablesmentioning

confidence: 99%

“…28 Since 2010, all inhabitants of the Principality of Liechtenstein aged between 25 and 41 years have been enrolled into a prospective cohort study. Main exclusion criteria were current intake of antidiabetic drugs, a body mass index (BMI) >35 kg/m 2 , established cardiovascular disease, or any other severe illness.…”

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confidence: 99%

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Glucagon-Like Peptide-1 and Blood Pressure in Young and Healthy Adults from the General Population

et al. 2015

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All study participants included in the current analysis are participants of the prospective genetic and phenotypic determinants of BP and other cardiovascular risk factors (GAPP) study. Detailed information Abstract-Hypertension and diabetes mellitus are highly correlated, but the underlying mechanisms are only partly understood.Therefore, the aim of our study was to investigate the relationships between plasma levels of glucagon-like peptide-1, a key factor in the regulation of glucose homeostasis, and various blood pressure indices. Healthy adults aged 25 to 41 years were enrolled in a population-based study. Established cardiovascular disease, diabetes mellitus, or a body mass index >35 kg/m 2 were exclusion criteria. Fasting plasma glucagon-like peptide-1 levels as determined with a novel high-sensitive assay and ambulatory blood pressure data were available in 1479 participants not using antihypertensive treatment. Median age of our population was 38 years. Mean systolic and diastolic blood pressure across increasing glucagon-like peptide-1 quartiles were 120.6, 122.8, 123.2, and 124.9 mm Hg and 77.1, 78.7, 78.9, and 79.9 mm Hg, respectively. We found a linear relationship of glucagon-like peptide-1 with 24-hour ambulatory blood pressure after multivariable adjustment (β per 1 log-unit increase 2.01; 95% confidence interval, 1.02-3.00; P<0.0001 for systolic and 1.22; 0.47-1.97; P=0.002 for diastolic blood pressure). In separate analyses, glucagon-like peptide-1 was significantly related to both awake (β per 1 logunit increase 2.05; 1.02-3.09; P=0.0001 for systolic and 1.15; 0.35-1.96; P=0.005 for diastolic blood pressure) and asleep blood pressure (β per 1 log-unit increase 1.34; 0.26-2.42; P=0.01 for systolic and 1.05; 0.26-1.84; P=0.009 for diastolic blood pressure). In conclusion, plasma levels of glucagon-like peptide-1 are significantly associated with both systolic and diastolic blood pressure levels. (Hypertension. 2015;65:306-312.

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Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population

et al. 2016

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Genetic and phenotypic determinants of blood pressure and other cardiovascular risk factors (GAPP)

Abstract: GAPP affords an excellent opportunity to assess genetic and phenotypic predictors of cardiovascular risk factors and their progression over time in young and healthy adults from the general population.

Cited by 30 publications

References 44 publications

Age-Specific Differences Between Conventional and Ambulatory Daytime Blood Pressure Values

Age-Specific Differences Between Conventional and Ambulatory Daytime Blood Pressure Values

Glucagon-Like Peptide-1 and Blood Pressure in Young and Healthy Adults from the General Population

Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population

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