Genetic and Non-Genetic Determinants of Circulating Levels of Adiponectin in a Cohort of Chilean Subjects

Lanas, Fernando; Serón, Pamela; Saavedra, Nicolás; Ruedlinger, Jenny; Salazar, Luis A.

doi:10.1007/s40291-015-0146-3

Cited by 9 publications

(6 citation statements)

References 40 publications

(52 reference statements)

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“…Lanas et al (2015) performed a study on a population of 108 adult patients, divided into four groups of 27 people depending on sex and obesity. The relationship of adiponectin and both clinical and genetic factors was studied.…”

Section: Adiponectin -The Adipokine Of Special Rolementioning

confidence: 99%

The genetic basis of obesity complications

Skrypnik

Suliburska

Skrypnik

et al. 2017

Acta Sci Pol Technol Aliment

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Intensive research is currently being performed into the genetic background of excess body mass complications such as diabetes, cardiovascular disorders, especially atherosclerosis and coronary heart disease. Chronic inflammation is an important process in the pathogenesis of obesity, wherein there is an aberrant expression of genes encoding adipokines. Visceral tissue is characterized by a higher expression and secretion of interleukin-8, interleukin-1ß and plasminogen activator inhibitor 1 in the subcutaneous tissue secretion of leptin prevails. An important complication of obesity is obstructive sleep apnea, often observed in PraderWilli syndrome. The genetic background of sleep apnea may be a polymorphism of the SREBF1 gene. The consequence of excess body mass is metabolic syndrome, which may be related to the occurrence of the rs926198 variant of gene encoding caveolin-1. The genes of transcription factor TCF7L2 and PPAR-γ2 take part in the pathogenesis of diabetes development. It has been demonstrated that oncogenes FOS, FOSB, and JUN may be co-responsible not only for obesity but also for osteoporosis and colorectal cancer. It has been shown that weight loss causes a modification in the expression of about 100 genes involvedt in the production of substances such as cytokines and other responsible for chronic inflammation in obesity. In future studies on the complications of obesity, such scientific disciplines as proteomics, peptidomics, metabolomics and transcriptomics should be used. The aim of this study is to present the current state of knowledge about the genetic basis of obesity complications.

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Section: Adiponectin -The Adipokine Of Special Rolementioning

confidence: 99%

The genetic basis of obesity complications

Skrypnik

Suliburska

Skrypnik

et al. 2017

Acta Sci Pol Technol Aliment

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“…1. A total of 99 studies on the associations between the polymorphisms in ADIPOQ and the circulating levels of adiponectin and/or lipids were identified [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. The details of the 99 studies enrolled in the meta-analysis are shown in table S1.…”

Section: Literature Search and Details Of The Enrolled Studiesmentioning

confidence: 99%

“…Sixty-one studies [21,24,26,27,[29][30][31][32][33] presented adiponectin and/or lipid data of the subjects with different genotypes of the rs2241766 polymorphism, among them 80 comparisons were distinguished according to ethnicity and health condition. A total of 21 361 subjects were included in the 61 studies or in the 80 comparisons, 58.16 % of them had TT genotype, and the rest had GT or GG genotype (table S4).…”

Section: Literature Search and Details Of The Enrolled Studiesmentioning

confidence: 99%

“…Several studies concluded that G allele of the rs266729 polymorphism was associated with decreased adiponectin levels [19][20][21], while data from other literature did not support this conclusion [22][23][24]. The effects of the rs1501299 and rs2241766 polymorphisms on the circulating adiponectin and lipid levels were also inconsistent in various populations [21,[25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

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Associations of the Polymorphisms in ADIPOQ with Circulating Levels of Adiponectin and Lipids: A Meta-Analysis

Jia

et al. 2021

Horm Metab Res

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The relationships between the rs266729, rs1501299, and rs2241766 polymorphisms in adiponectin gene (ADIPOQ) and circulating levels of adiponectin and lipids remain to be clarified. Databases including PubMed and Embase were searched for eligible studies. The random-effects model was used, and standardized mean difference (SMD) with 95% confidence interval (CI) was calculated to estimate the differences in circulating levels of adiponectin and lipids between the subjects with different genotypes. A total of 12 810, 17 319, and 21 361 subjects were identified in the analyses for the rs266729, rs1501299, and rs2241766 polymorphisms, respectively. G allele carriers of the rs266729 polymorphism had lower levels of adiponectin (SMD=–0.28, 95% CI=–0.43 to–0.12) and high-density lipoprotein cholesterol (HDL-C) (SMD=–0.10, 95% CI=–0.17 to–0.02) than CC homozygotes; T allele carriers of the rs1501299 polymorphism had higher levels of adiponectin (SMD=0.21, 95% CI=0.05 to 0.36) and HDL-C (SMD=0.09, 95% CI=0.04 to 0.15) and lower levels of triglycerides (SMD=–0.06, 95% CI=–0.12 to–0.01) than GG homozygotes; G allele carriers of the rs2241766 polymorphism had lower levels of adiponectin (SMD=–0.18, 95% CI=–0.31 to–0.05) and HDL-C (SMD=–0.12, 95% CI=–0.20 to–0.04) than TT homozygotes. This meta-analysis suggests that the rs266729, rs1501299, and rs2241766 polymorphisms of ADIPOQ are significantly associated with circulating levels of adiponectin and lipids, which may partly explain the associations between these polymorphisms and coronary artery disease.

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“…The adiponectin gene polymorphism is given as the cause of changes in the amount of adiponectin mRNA in adipose tissue of some obese subjects on a lowcalorie diet (Clement and Langin, 2007). Lanas et al (2015) performed a study on a population of 108 adult patients, divided into four groups of 27 people depending on sex and obesity. The relationship of adiponectin and both clinical and genetic factors was studied.…”

Section: Adiponectin -The Adipokine Of Special Rolementioning

confidence: 99%