Genetic and Neurophysiological Correlates of the Age of Onset of Alcohol Use Disorders in Adolescents and Young Adults

Chorlian, David B.; Rangaswamy, Madhavi; Manz, Niklas; Wang, Jen Chyong; Dick, Danielle M.; Almasy, Laura; Bauer, Lance O.; Bucholz, Kathleen K.; Foroud, Tatiana; Hesselbrock, Victor; Kang, Sun J.; Kramer, John; Kuperman, Samuel; Nürnberger, John I.; Rice, John P.; Schuckit, Marc A.; Tischfield, Jay A.; Edenberg, Howard J.; Goate, Alison M.; Bierut, Laura J.; Porjesz, Bernice

doi:10.1007/s10519-013-9604-z

Cited by 18 publications

(23 citation statements)

References 92 publications

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“…Work in humans suggests that genetic contributions to alcohol abuse may be considerably stronger during adulthood compared to adolescence (van Beek et al ., 2012, Edwards et al ., 2015; also see Chorlian et al ., 2013; Guo et al ., 2015). Indeed, adolescent B6 mice voluntarily drink more ethanol than adults, an ontogenetic difference not observed in mice from the DBA/2J strain (Moore et al ., 2010).…”

Section: Discussionmentioning

confidence: 96%

Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice

Panksepp

Rodriguez

Ryabinin

2016

Genes Brain and Behavior

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With its ease of availability during adolescence, sweetened ethanol (‘alcopops’) is consumed within many contexts. We asked here whether genetically based differences in social motivation are associated with how the adolescent social environment impacts voluntary ethanol intake. Mice with previously described differences in sociability (BALB/cJ, C57BL/6J, FVB/NJ and MSM/MsJ strains) were weaned into isolation or same-sex pairs (postnatal day 21), and then given continuous access to two fluids on postnatal days 34–45: One containing water and the other containing a ascending series of saccharin-sweetened ethanol (3-to-6-to-10%). Prior to the introduction of ethanol (postnatal days 30–33), increased water and food intake was detected in some of the isolation-reared groups, and controls indicated that isolated mice also consumed more ‘saccharin-only’ solution. Voluntary drinking of ‘ethanol-only’ was also higher in a subset of the isolated groups on postnatal days 46–49. However, sweetened ethanol intake was increased in all isolated strain-by-sex combinations irrespective of genotype. Surprisingly, blood ethanol concentration was not different between these isolate and socially housed groups 4 hours into the dark phase. Using lickometer-based measures of intake in FVB mice, we identified that a predominance of increased drinking during isolation transpired outside of the typical circadian consumption peak, occurring ≈8.5 hours into the dark phase, with an associated difference in blood ethanol concentration. These findings collectively indicate that isolate housing leads to increased consumption of rewarding substances in adolescent mice independently of their genotype, and that for ethanol this may be due to when individuals drink during the circadian cycle.

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Section: Discussionmentioning

confidence: 96%

Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice

Panksepp

Rodriguez

Ryabinin

2016

Genes Brain and Behavior

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“…A study by Sovio et al (2009) found age (infancy compared to puberty) but no sex specific genotypic effects for a number of SNPs (Table 2 in Sovio et al (2009)) for height velocity. More peripheral instances of age variation in genotypic effect were shown in Chorlian et al (2013) where some CHRM2 SNPs were found to affect risk for the onset of alcohol dependence in adolescents and young adults only in those who became alcohol dependent under the age of 16 and in Hill et al (2013), mentioned above.…”

Section: Discussionmentioning

confidence: 96%

Genetic correlates of the development of theta event related oscillations in adolescents and young adults

Chorlian

Rangaswamy

Manz

et al. 2017

International Journal of Psychophysiology

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The developmental trajectories of theta band (4–7 Hz) event-related oscillations (EROs), a key neurophysiological constituent of the P3 response, were assessed in 2170 adolescents and young adults ages 12 to 25. The theta EROs occurring in the P3 response, important indicators of neurocognitive function, were elicited during the evaluation of task-relevant target stimuli in visual and auditory oddball tasks. Associations between the theta EROs and genotypic variants of 4 KCNJ6 single nucleotide polymorphisms (SNPs) were found to vary with age, sex, scalp location, and task modality. Three of the four KCNJ6 SNPs studied here were found to be significantly associated with the same theta EROs in adults in a previous family genome wide association study. Since measures of the P3 response have been found to be a useful endophenotypes for the study of a number of clinical and behavioral disorders, studies of genetic effects on its development in adolescents and young adults may illuminate neurophysiological factors contributing to the onset of these conditions.

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“…These findings are in concert with prior research that has shown higher rates of alcohol dependence in individuals who begin drinking at an early age. 33 …”

Section: Discussionmentioning

confidence: 99%

A Long-Term Longitudinal Examination of the Effect of Early Onset of Alcohol and Drug use on Later Alcohol Abuse

2015

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Background Early onset of alcohol use has been linked to later alcohol problems in adulthood. Currently, it is not clear whether early onset of marijuana and tobacco use similarly predicts alcohol problems. Moreover, most studies examining the effect of early substance use onset on later problems only have followed youth into their early 20s. Therefore, the primary goal of this study was to examine whether early onset of alcohol, marijuana, and tobacco use predicts alcohol problems beyond the transition to adulthood. Methods The sample included 225 15-19 year old youth (60% girls; 62% Caucasian) who were surveyed in 1993-1998 (Time 1), 1998–2003 (Time 2), and 2003-2007 (Time 3). Participants reported their age of onset for regular drinking, tobacco use, and marijuana use. At each time of measurement, they also completed surveys relating to their alcohol use and abuse. Results Participants with an earlier age of onset of drinking regularly scored higher on the Michigan Alcoholism Screening Test (MAST) and drank more frequently to get high and drunk throughout their twenties. Tobacco use onset and marijuana use onset were not associated with later alcohol use or abuse. Conclusions Results from this study suggest that the relationship between the onset of substance use and later substance abuse may be substance specific. Of note, early onset of regular drinking was associated with alcohol problems during adulthood, underscoring the importance of delaying the onset of regular alcohol use among youth.

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Genetic and Neurophysiological Correlates of the Age of Onset of Alcohol Use Disorders in Adolescents and Young Adults

Cited by 18 publications

References 92 publications

Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice

Sweetened ethanol drinking during social isolation: enhanced intake, resistance to genetic heterogeneity and the emergence of a distinctive drinking pattern in adolescent mice

Genetic correlates of the development of theta event related oscillations in adolescents and young adults

A Long-Term Longitudinal Examination of the Effect of Early Onset of Alcohol and Drug use on Later Alcohol Abuse

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