Abstract:We applied structural equation modeling to genome-wide association studies (GWAS) of the items in a Neuroticism questionnaire. We categorized significant genetic variants as acting either through the Neuroticism general factor, through other factors measured by the questionnaire, or through paths independent of any factor. Bioinformatic analysis showed that the genetic variants associated with the Neuroticism general factor tend to lie near or within genes expressed in the brain. Enriched gene sets suggest beh… Show more
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