Genetic and molecular biology of bladder cancer among Iranian patients

Mojarrad, Majid; Moghbeli, Meysam

doi:10.1002/mgg3.1233

Cited by 13 publications

(8 citation statements)

References 134 publications

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“…The BCa is also three to four times more frequent among males compared with females [5]. The prevalence of BCa can be associated with environmental and genetic determinants, which are different among racial/ethnic groups [6,7]. Based on histopathologic features of tumor cells, there are three main types of BCa including: transitional cell carcinoma, squamous cell carcinoma, and adenocarcinoma, which account for 90, 5%, and less than 2% of BCa cases, respectively [8].…”

Section: Introductionmentioning

confidence: 99%

“…Clinicopathological features are commonly used to predict tumor growth, recurrence, and patient’s survival. However, the gene expression profiling and molecular pathway analysis have gained growing attention as a novel and promising methods for the prediction of disease course and prognosis in BCa patients [ 7 , 30 , 31 ]. Since, tyrosine-kinases have essential roles in BCa progression, in present review we have summarized all of the studies which have been assessed the role of tyrosine-kinases in BCa patients in the world (Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Role of tyrosine kinases in bladder cancer progression: an overview

Zangouei¹,

Barjasteh²,

Rahimi³

et al. 2020

Cell Commun Signal

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Background: Bladder cancer (BCa) is a frequent urothelial malignancy with a high ratio of morbidity and mortality. Various genetic and environmental factors are involved in BCa progression. Since, majority of BCa cases are diagnosed after macroscopic clinical symptoms, it is required to find efficient markers for the early detection. Receptor tyrosine-kinases (RTKs) and non-receptor tyrosine-kinases (nRTKs) have pivotal roles in various cellular processes such as growth, migration, differentiation, and metabolism through different signaling pathways. Tyrosine-kinase deregulations are observed during tumor progressions via mutations, amplification, and chromosomal abnormalities which introduces these factors as important candidates of anti-cancer therapies. Main body: For the first time in present review we have summarized all of the reported tyrosine-kinases which have been significantly associated with the clinicopathological features of BCa patients. Conclusions: This review highlights the importance of tyrosine-kinases as critical markers in early detection and therapeutic purposes among BCa patients and clarifies the molecular biology of tyrosine-kinases during BCa progression and metastasis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of tyrosine kinases in bladder cancer progression: an overview

Zangouei¹,

Barjasteh²,

Rahimi³

et al. 2020

Cell Commun Signal

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“…Therefore, our survival analyze for this period did not provide additional results. Second, we did not include other factors that may affect OS, such as economic conditions (31), marital status (32), genetic factors (33)(34)(35), posttreatment care status (36,37), and patient physical status. The inclusion of these factors would further make the nomogram more accurate.…”

Section: Discussionmentioning

confidence: 99%

Incidence, prognostic factors and survival in bladder cancer patients: a population-based study

Shun-de¹,

Ge²,

Zhang³

2022

Transl Cancer Res TCR

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Background: The aim of this study was to investigate the incidence, epidemiologic characteristics, prognostic factors and survival of patients with bladder cancer.Methods: Bladder cancer patients diagnosed between 2010 and 2015 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox proportional hazards regression analyses were used to identify the independent prognostic factors for overall survival. Kaplan-Meier survival analysis and nomogram analysis were constructed based on the identified independent prognostic factors.Results: A total of 95,329 eligible bladder cancer patients were included in this study. Eight independent risk factors, including age, histologic type, race, tumor, node and metastasis (TNM) stage, American Joint Committee on Cancer (AJCC) stage, surgery, tumor metastasis and summary stage, were recognized by using multivariate logistic regression models. By comprising these factors, a predictive nomogram was constructed to predict the 1-, 3-, and 5-year overall survival possibilities. The concordance index and calibration curve showed that the nomogram had robust and accurate performance.Conclusions: Bladder cancer is the most common cancer of the urinary system, but the overall incidence has been decreasing yearly since 1992. Our results demonstrate eight factors significantly associated with overall survival in bladder cancer patients. Based on these factors, we established and validated a nomogram, which has the potential to provide an individualized prediction of overall survival in patients with bladder cancer.

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“…Regarding the chemotherapeutic resistance, many patients are faced with side effects without any efficient benefit. Genetic factors are associated with drug resistance through regulation of drug efflux, DNA repair, cell cycle, and apoptosis [11][12][13]. Non-coding RNAs (ncRNAs) are a class of RNAs including long non-coding RNAs (lncRNA), micro RNAs (miRNA), and circular RNAs (circRNA) which are involved in post transcriptional regulation.…”

Section: Introductionmentioning

confidence: 99%

Non coding RNAs as the critical factors in chemo resistance of bladder tumor cells

et al. 2020

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Background Bladder cancer (BCa) is the ninth frequent and 13th leading cause of cancer related deaths in the world which is mainly observed among men. There is a declining mortality rates in developed countries. Although, the majority of BCa patients present Non-Muscle-Invasive Bladder Cancer (NMIBC) tumors, only 30% of patients suffer from muscle invasion and distant metastases. Radical cystoprostatectomy, radiation, and chemotherapy have proven to be efficient in metastatic tumors. However, tumor relapse is observed in a noticeable ratio of patients following the chemotherapeutic treatment. Non-coding RNAs (ncRNAs) are important factors during tumor progression and chemo resistance which can be used as diagnostic and prognostic biomarkers of BCa. Main body In present review we summarized all of the lncRNAs and miRNAs associated with chemotherapeutic resistance in bladder tumor cells. Conclusions This review paves the way of introducing a prognostic panel of ncRNAs for the BCa patients which can be useful to select a proper drug based on the lncRNA profiles of patients to reduce the cytotoxic effects of chemotherapy in such patients.

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Genetic and molecular biology of bladder cancer among Iranian patients

Cited by 13 publications

References 134 publications

Role of tyrosine kinases in bladder cancer progression: an overview

Role of tyrosine kinases in bladder cancer progression: an overview

Incidence, prognostic factors and survival in bladder cancer patients: a population-based study

Non coding RNAs as the critical factors in chemo resistance of bladder tumor cells

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