Genetic and immunophenotypic profile of IGH@ rearrangement detected by fluorescence in situ hybridization in 149 cases of B-cell chronic lymphocytic leukemia

Cutaneous Borreliosis With a T-Cell–Rich Infiltrate and Simultaneous Involvement by B-Cell Chronic Lymphocytic Leukemia With t(14;18)(q32;q21)

“…In addition, occasional cases of CLL/small lymphocytic lymphoma with t(14;18) have been reported. 28,29 In our case, the break in the BCL2 gene detected in a portion of the cellular infiltrate is compatible with the presence of the same clone of B-CLL cells with a translocation t(14;18)(q32;q21) as previously detected in the bone marrow of this patient. This is interesting because morphologically and by immunohistochemistry, the B-CLL infiltrate was below the detection limit.…”

Population-based characterization of the genetic landscape of chronic lymphocytic leukemia patients referred for cytogenetic testing in British Columbia, Canada: the role of provincial laboratory standardization

“…We recognize, however, that D€ ohner's cohort included a mixture of pre-and posttreatment samples, and, therefore, we also compared our prevalence rates with a more recent clinical trial cohort about to start first-line therapy. As seen in our cohort, deletion of 11q (27,28,30) and deletion of 6q (27,28) have been consistently reported at lower frequencies and, conversely, IGH translocations (12,30e32) and trisomy 12 (10,27) have been reported to occur at higher frequencies. These differences likely reflect variations in the populations studied, including whether they were clinical trial or population-based cohorts.…”

Chronic lymphocytic leukemia with a FGFR3 translocation: case report and literature review of an uncommon cytogenetic event

“…IgH translocations are a common occurrence in CLL, with reported frequencies in the literature ranging from 9.6e31.0%. In a study of 124 CLL patients, Lu et al (7) reported the t(14;19) as the most common cytogenetic alteration involving the IgH gene, with an incidence of 7% in their patient population. The t (8;14), which is associated with Burkitt's lymphoma, is an uncommon occurrence in CLL and was seen in a single case.…”