Genetic and Immunological Characterization of Brain Metastases from Solid Cancers
SHOICHI DEGUCHI,
YASUTO AKIYAMA,
KOICHI MITSUYA
et al.
Abstract:Background/Aim: Brain metastasis, a leading cause of cancer death, is a clinical challenge. Recently, genetic characterization of brain metastatic lesions based on next generation sequencing-based advanced technologies, such as single-cell RNA sequencing, has been performed to develop novel efficient therapies. The present study aimed to investigate brain-metastasis-specific biomarkers as well as relevant prognostic factors. Patients and Methods: The genetic profiles and expression levels of immune response-as… Show more
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