Genetic and Hormonal Determinations in a Pair of Identical Twins with Early Onset Psoriasis Vulgaris: Case Report and a Brief Review of the Literature

Roman, Iulia Ioana; Orăsan, Meda Sandra; Coneac, Andrei; Marina, Elena Mihaela; Pop, A.; Orăsan, Remus Ioan

doi:10.1515/rrlm-2017-0021

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“…The etiopathogenesis of psoriasis is multifactorial due to the interaction between genetic and enviromental factors. The genetic factors influence the formation of the disease (3,4). While psychiatric drugs, antigenic stimulation, and physical or emotional stress play an important role in triggering symptoms, most of the studies suggest that a strong genetic component causes disease susceptibility (5).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Relation Between FAS, FASLG Polymorphisms and Serum Fas, FasL Levels in Patients with Psoriasis

Duran

Kasap

Güneşaçar

et al. 2018

Revista Romana De Medicina De Laborator

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Background: Psoriasis is a multifactorial and inflammatory chronic skin disease indicated with T-cell-mediated keratinocyte hyper-proliferation. Demographic, epidemiological (family, twin), serological, and genetic studies have clearly demonstrated that psoriasis is a polygenic and multifactorial disease. Aim: The objectives of the study are; to determine the prevalence of the polymorphisms of FAS (Fas cell surface receptor gene) -671 A>G (rs:1800682) and FASLG (Fas ligand gene) -844 T>C (rs:763110), to investigate the serum levels of sFas and sFasL, and also to discover any relationship between gene polymorphisms and serum levels in psoriatic patients. Material and Methods: 50 treated and 69 untreated patients, and 140 healthy controls were included in the study. Polymorphisms were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The serum levels were measured in randomly selected treated (39) and untreated (40) patients, also in 84 healthy controls using micro-ELISA technique. Results: There was no statistical difference between polymorphisms in the patient and control groups. However, sFas and sFasL levels in both treated and untreated patients were higher than that of the controls. Conclusion: The investigated FAS and FASLG polymorphisms were not found to be directly associated with the psoriasis. Elevated sFas and sFasL levels in psoriatic patients showed that these factors may possess a significant role in the pathogenesis of psoriasis.

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Section: Introductionmentioning

confidence: 99%

Investigation of the Relation Between FAS, FASLG Polymorphisms and Serum Fas, FasL Levels in Patients with Psoriasis

Duran

Kasap

Güneşaçar

et al. 2018

Revista Romana De Medicina De Laborator

View full text Add to dashboard Cite

show abstract

Genetic and Hormonal Determinations in a Pair of Identical Twins with Early Onset Psoriasis Vulgaris: Case Report and a Brief Review of the Literature

Abstract: Psoriasis vulgaris is a chronic inflammatory dermatosis with major impact on patients' life quality. The etiopathogenesis is multifactorial, depending on complex interactions between genetic and environmental factors.We

Cited by 1 publication

References 20 publications

Investigation of the Relation Between FAS, FASLG Polymorphisms and Serum Fas, FasL Levels in Patients with Psoriasis

Investigation of the Relation Between FAS, FASLG Polymorphisms and Serum Fas, FasL Levels in Patients with Psoriasis

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