Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss

Arias-Sosa, Luis Alejandro; Acosta, Iván Darío; Lucena-Quevedo, Elkin; Moreno-Ortíz, Harold; Esteban-Pérez, Clara; Forero-Castro, Maribel

doi:10.1007/s10815-017-1108-y

Cited by 67 publications

(44 citation statements)

References 82 publications

(109 reference statements)

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“…More and more evidence supported that these dynamic morphological and functional changes during the menstrual cycles are epigenetically regulated (Grimaldi et al, 2011;Tamura et al, 2014;Katoh et al, 2018). Epigenetic modifications mainly refer to the DNA methylation and histone modifications, of which histone methylation and acetylation are most studied (Zhou et al, 2011), that aberrant epigenetic modifications may be associated with the progress of endometriosis (Izawa et al, 2013;Forte et al, 2014;Zhang et al, 2017), recurrent miscarriage (Arias-Sosa et al, 2018;Yu et al, 2018), and implantation failure. For instance, HDAC3 is critical for endometrial receptivity, such that loss of HDAC3 caused an impaired decidualization through the abnormal activation of COL1A1/2 genes in humans (Kim and Yoo, 2019).…”

Section: Discussionmentioning

confidence: 99%

Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity

Zhou

Zhang

et al. 2020

Front. Cell Dev. Biol.

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Section: Discussionmentioning

confidence: 99%

Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity

Zhou

Zhang

et al. 2020

Front. Cell Dev. Biol.

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“…Primary RM stands for the collapse of several pregnancies in a woman without any previous live birth while secondary RM means multiple pregnancy failures in a woman after at least one successful pregnancy ( Silver et al, 2011 , Kolte et al, 2015 , El Hachem et al, 2017 ). The various known set of causes associated with RM include parental chromosomal aberrations, uterine malformations, infectious diseases, endocrine problems, and autoimmune defects; nevertheless, the causes remain idiopathic in around 50% of RM cases ( Ford and Schust, 2009 , Fritz and Speroff, 2012 , Jeve and Davies, 2014 , Arias-Sosa et al, 2018 , Ali et al, 2020 ) ( Fig. 1 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients

Ali

Majid

Ali

et al. 2020

Saudi Journal of Biological Sciences

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The purpose of this study was to evaluate etiology and pregnancy outcome of recurrent miscarriage women. The enrolled patients (280) were evaluated for Triiodothyronine, Thyroxine, Thyroid stimulating hormone, prolactin, chromosomal analysis, Haemoglobin A1C, blood sugar, Magnetic resonance imaging, 3D-ultrasound, auto-antibodies profile (antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant, antinuclear antibodies, anti-thyroid antibodies and β2 glycoprotein1), torch profile (Toxoplasmo gondii, rubella, cytomegalo virus and herpes simplex virus), blood vitamin D3 levels, psychological factors, Body mass index and thrombotic factors (protein S and C deficiency, Prothrombin G20210A mutation, anti-thrombin III, Factor V Leiden and Methylenetetrahydrofolate reductase mutation), uterosalpingography (hysteronsalpingography) and hysteroscopy. The therapeutic regimens either singly or combined were employed for the treatment of recurrent miscarriage patients on the basis of etiology (single or multiple) and include intravenous immunoglobulin, low molecular weight heparin, low dose aspirin, levothyroxine, progesterone, folic acid, human chorionic gonadotrophin, vitamin D3, psychotherapy, genetic counselling. However, patients with idiopathic recurrent miscarriage were treated with progesterone supplementation, anticoagulation and/or immune modulatory agents. The incidence of primary recurrent miscarriage was highest and most of the women experienced recurrent miscarriage during first trimester. Endocrinological disorders (39%) were found as the major pathological factor for recurrent miscarriage. Other factors include uterine abnormalities (5.7%), vitamin D3 deficiency (3.5%), psychological factors (3.2%) infection (3.6%), autoimmune abnormalities (1.8%) and protein S deficiency (1.8%). However, 40% cases were idiopathic. The overall live birth rate achieved after the management of recurrent miscarriage patients was 75.7%. Enocrinopathy was the major cause of recurrent miscarriage. The overall live birth rate achieved was 75.7% with highest pregnancy outcome in secondary recurrent miscarriage patients after the management.

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“…15%, out of which 80% occur within the first trimester. Recurrent miscarriages account for 1-2% of cases [1,2,3,4].…”

Section: Introductionmentioning

confidence: 99%

Quality of life, Social Support and Self-Efficacy in Women After A Miscarriage

Iwanowicz-Palus

Mróz

Bień

2020

Preprint

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Background Pregnancy loss is typically experienced as a traumatic, critical event, which may lead to secondary psychological health disorders. Its burden involves both the experience of loss and related medical issues, which are associated with pain, hospitalization, limitation in one’s social roles, decreased sense of security, and changes in one’s perceived quality of life. The purpose of the present study was to evaluate levels of quality of life (QoL), social support and self-efficacy among women who had suffered a miscarriage.Methods The study was performed using a diagnostic survey method with questionnaires administered to 610 patients hospitalized due to spontaneous pregnancy loss in hospitals in Lublin (Poland). The instruments used were: the Berlin Social Support Scales (BSSS), the Generalized Self-Efficacy Scale (GSES), the WHOQoL–BREF questionnaire, and a standardized interview questionnaire.Results Respondents rated their overall QoL (3.90 points) higher than their overall perceived health (3.66). In terms of social support, the highest scores were noted for perceived available instrumental support (M = 3.78), perceived available emotional support (M = 3.68) and actually received support (M = 3.60). The mean generalized self-efficacy score among the women after pregnancy loss was 30.29. Respondents’ QoL was significantly correlated with multiple social support subscales and self-efficacy (p < 0.05). Conclusions Women after a miscarriage perceive their overall QoL as better than their overall health, while reporting the poorest QoL in the psychological domain. They also have a high level of self-efficacy. Regarding the types of social support, perceived available support, both instrumental and emotional, and actually received support was rated highly. Social support and self-efficacy contributed to better perceived QoL among the respondents.

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Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss

Cited by 67 publications

References 82 publications

Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity

Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity

Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients

Quality of life, Social Support and Self-Efficacy in Women After A Miscarriage

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