Genetic and Epigenetic Regulation of Interferon Regulatory Factor Expression: Implications in Human Malignancies

Fragale, A; Marsili, Giulia; Battistini, Angela

doi:10.4172/2157-7412.1000205

Cited by 2 publications

(1 citation statement)

References 172 publications

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“…Interferon-inducible protein p78 5-Aza-dC Kulaeva et al, 2003 suppressor genes. No wonder that IRFs can carry both genetic and epigenetic modifications, and their interrelations with the IFN unresponsiveness and association with tumour progression have been described in a number of studies (Fragale et al, 2013). Analysis of a number of tumour cell lines revealed that particular IRFs were differentially expressed in various gastric cancer cells, and frequent suppression of IRF4, IRF5 and IRF8 was documented (Yamashita et al, 2010).…”

Section: Mx1mentioning

confidence: 99%

Epigenetic View on Interferon γ Signalling in Tumour Cells

Selinger,

Reiniš

2018

Fol. Biol.

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IFN-γ is a pleiotropic cytokine crucial for both innate and adaptive immunity, which also plays a critical role in immunological surveillance of cancer. Genetic defects or gene silencing in the IFN-γ signal transduction pathways as well as in the expression of IFN-γ-regulated genes represent frequent mechanisms by which tumour cells can escape from immune responses. Epigenetic control of the IFN-γ signalling pathway activation associated with epigenetic changes in the corresponding regulatory gene regions, such as chromatin remodelling, histone acetylation and methylation, and DNA demethylation is frequently dysregulated in tumour cells. Epigenetic silencing of the IFN-γ regulatory pathway components, as well as of the IFN-γ-regulated genes crucial for tumour cell recognition or induction of anti-tumour immune responses, has been documented in various cancer models. Expression of both IFN-γ signalling pathway components and selected IFN-γ-regulated genes can be influenced by epigenetic modifiers, namely DNA methyltransferase and histone deacetylase inhibitors. These agents thus can mimic, restore, or boost the immunomodulatory effects of IFN-γ in tumour cells, which can contribute to their anti-tumour therapeutic efficacies and justifies their potential use in combined epigenetic therapy with immunotherapeutic approaches.

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Section: Mx1mentioning

confidence: 99%

Epigenetic View on Interferon γ Signalling in Tumour Cells

Selinger,

Reiniš

2018

Fol. Biol.

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Molecular characterization of interferon regulatory factor 1 in Bubalus bubalis

Stafuzza¹,

Borges²,

Amaral-Trusty³

2015

Genet. Mol. Res.

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ABSTRACT. Interferon regulatory factor 1 (IRF1) is functionally diverse in the regulation of immune response and is considered to be an important candidate gene for studying disease susceptibility in mammals. In this paper, we characterized the whole sequence of the IRF1 gene in river buffalo (Bubalus bubalis) and compared genomic and the amino acid sequences between different species. The buffalo IRF1 gene was 7099 bp long and organized into 10 exons and nine introns. Its molecular structure showed exactly the same number of exons (10) and introns (nine) in bovids, mice, horses, humans, and chickens. However, rats did not have exon 5, but had the largest exon 4, which suggests that exon 5 was incorporated into exon 4. The coding and the amino acid sequences of the gene showed that identity varied from 73 to 99% at the coding sequence level and from 61 to 100% at the amino acid level when compared with other mammals and chickens. Comparative analysis of the gene sequence between two different buffalo breeds, Murrah and Mediterranean, revealed six potential SNPs that are primarily located in the 5' and 3'UTRs.

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Genetic and Epigenetic Regulation of Interferon Regulatory Factor Expression: Implications in Human Malignancies

Cited by 2 publications

References 172 publications

Epigenetic View on Interferon γ Signalling in Tumour Cells

Epigenetic View on Interferon γ Signalling in Tumour Cells

Molecular characterization of interferon regulatory factor 1 in Bubalus bubalis

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