Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence

Martin, Elizabeth M.; Stýblo, Miroslav; Fry, Rebecca C.

doi:10.2217/epi-2016-0097

Cited by 46 publications

(27 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, a number of studies have shown that arsenic can play a role in glucose dysfunction and insulin resistance (Tseng 2004). Arsenic increases the production of ROS and free radicals, which have been implicated in chronic inflammation and apoptosis of pancreatic β-cells (Martin et al 2017). Arsenic also upregulates the expression of inflammatory genes such as NFkB, tumor necrosis factor- α (TNF- α ), and interleukin (IL)-6 (Tseng 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Arsenic also upregulates the expression of inflammatory genes such as NFkB, tumor necrosis factor- α (TNF- α ), and interleukin (IL)-6 (Tseng 2004). These inflammatory factors can injure the pancreas and interfere with glucose-mediated insulin secretion (Martin et al 2017; Walton et al 2004). Several environmental pollutants have been shown to impair thermogenic adipose tissue involved in glucose and lipid metabolism (Zhang et al 2016), and arsenic’s effect on adiposity, specifically on brown and beige adipocytes, may also be a mechanism by which it affects diabetes risk (Maull et al 2012).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile

Castriota

Acevedo

Ferreccio

et al. 2018

Environmental Research

View full text Add to dashboard Cite

Background: The prevalence of type 2 diabetes (T2D) has nearly doubled since 1980. Elevated body mass index (BMI) is the leading risk factor for T2D, mediated by inflammation and oxidative stress. Arsenic shares similar pathogenic processes, and may contribute to hyperglycemia and β-cell dysfunction. Objectives: We assessed a unique situation of individuals living in Northern Chile with data on lifetime arsenic exposure to evaluate the relationship between arsenic and T2D, and investigate possible interactions with BMI. Methods: We analyzed data collected from October 2007-December 2010 from an arsenic-cancer case-control study. Information on self-reported weight, height, smoking, diet, and other factors were obtained. Diabetes was defined by self-reported physician-diagnoses or use of hypoglycemic medication. A total of 1053 individuals, 234 diabetics and 819 without known diabetes were included. Results: The T2D odds ratio (OR) for cumulative arsenic exposures of 610–5279 and ≥5280 µg/L-years occurring 40 years or more before interview were 0.97 (95% CI: 0.66–1.43) and 1.53 (95% CI: 1.05–2.23), respectively. Arsenic-associated T2D ORs were greater in subjects with increased BMIs. For example, the ORs for past cumulative exposures ≥5280 µg/L-years was 1.45 (95% CI: 0.74–2.84) in participants with BMIs <25 kg/m2 but 2.64 (95% CI: 1.14–6.11) in those with BMIs ≥30 kg/m2 (synergy index = 2.49, 95% CI: 0.87–7.09). Results were similar when people with cancer were excluded. Conclusions: These findings identify increased odds of T2D with arsenic exposure, which are significantly increased in individuals with excess BMI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile

Castriota

Acevedo

Ferreccio

et al. 2018

Environmental Research

View full text Add to dashboard Cite

show abstract

“…DNA methylation, histone modification and microRNA expression have been identified as the prominent epigenetic mechanisms of i As toxicity . i As alteration of epigenetic mechanisms has also been linked to an up‐regulation of cancer‐related genes, as well as a down‐regulation of programmed cell death .…”

Section: Mechanisms Involved In Arsenic Tumorigenesismentioning

confidence: 99%

State of the science review of the health effects of inorganic arsenic: Perspectives for future research

Tchounwou

Yedjou

Udensi

et al. 2018

Environmental Toxicology

126

View full text Add to dashboard Cite

Human exposure to inorganic arsenic (iAs) is a global health issue. Although there is strong evidence for iAs-induced toxicity at higher levels of exposure, many epidemiological studies evaluating its effects at low exposure levels have reported mixed results. We comprehensively reviewed the literature and evaluated the scientific knowledge on human exposure to arsenic, mechanisms of action, systemic and carcinogenic effects, risk characterization, and regulatory guidelines. We identified areas where additional research is needed. These priority areas include: (1) further development of animal models of iAs carcinogenicity to identify molecular events involved in iAs carcinogenicity; (2) characterization of underlying mechanisms of iAs toxicity; (3) assessment of genderspecific susceptibilities and other factors that modulate arsenic metabolism; (4) sufficiently powered epidemiological studies to ascertain relationship between iAs exposure and reproductive/ developmental effects; (5) evaluation of genetic/epigenetic determinants of iAs effects in children;and (6) epidemiological studies of people chronically exposed to low iAs concentrations.

show abstract

“…Other emerging risk factors for type 2 DM and CVD include the gut microbiome ( 256 – 258 ), gallbladder disease ( 259 ), environmental exposures ( 260 – 262 ), and the impact of sugar-sweetened beverages intake on satiety ( 263 ). Research on these emerging factors in Hispanics/Latinos has been limited.…”

Section: Etiology Of Type 2 Dm In Hispanics/latinosmentioning

confidence: 99%

From Sea to Shining Sea and the Great Plains to Patagonia: A Review on Current Knowledge of Diabetes Mellitus in Hispanics/Latinos in the US and Latin America

et al. 2017

View full text Add to dashboard Cite

The past two decades have witnessed many advances in the prevention, treatment, and control of diabetes mellitus (DM) and its complications. Increased screening has led to a greater recognition of type 2 diabetes mellitus (type 2 DM) and prediabetes; however, Hispanics/Latinos, the largest minority group in the US, have not fully benefited from these advances. The Hispanic/Latino population is highly diverse in ancestries, birth places, cultures, languages, and socioeconomic backgrounds, and it populates most of the Western Hemisphere. In the US, the prevalence of DM varies among Hispanic/Latino heritage groups, being higher among Mexicans, Puerto Ricans, and Dominicans, and lower among South Americans. The risk and prevalence of diabetes among Hispanics/Latinos are significantly higher than in non-Hispanic Whites, and nearly 40% of Hispanics/Latinos with diabetes have not been formally diagnosed. Despite these striking facts, the representation of Hispanics/Latinos in pharmacological and non-pharmacological clinical trials has been suboptimal, while the prevalence of diabetes in these populations continues to rise. This review will focus on the epidemiology, etiology and prevention of type 2 DM in populations of Latin American origin. We will set the stage by defining the terms Hispanic, Latino, and Latin American, explaining the challenges identifying Hispanics/Latinos in the scientific literature and databases, describing the epidemiology of diabetes—including type 2 DM and gestational diabetes mellitus (GDM)—and cardiovascular risk factors in Hispanics/Latinos in the US and Latin America, and discussing trends, and commonalities and differences across studies and populations, including methodology to ascertain diabetes. We will discuss studies on mechanisms of disease, and research on prevention of type 2 DM in Hispanics/Latinos, including women with GDM, youth and adults; and finalize with a discussion on lessons learned and opportunities to enhance research, and, consequently, clinical care oriented toward preventing type 2 DM in Hispanics/Latinos in the US and Latin America.

show abstract

Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence

Cited by 46 publications

References 78 publications

Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile

Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile

State of the science review of the health effects of inorganic arsenic: Perspectives for future research

From Sea to Shining Sea and the Great Plains to Patagonia: A Review on Current Knowledge of Diabetes Mellitus in Hispanics/Latinos in the US and Latin America

Contact Info

Product

Resources

About