Genetic and Epigenetic Aspects of Type 1 Diabetes Mellitus: Modern View on the Problem
Ildar Minniakhmetov,
Bulat Yalaev,
Rita Khusainova
et al.
Abstract:Omics technologies accumulated an enormous amount of data that advanced knowledge about the molecular pathogenesis of type 1 diabetes mellitus and identified a number of fundamental problems focused on the transition to personalized diabetology in the future. Among them, the most significant are the following: (1) clinical and genetic heterogeneity of type 1 diabetes mellitus; (2) the prognostic significance of DNA markers beyond the HLA genes; (3) assessment of the contribution of a large number of DNA marker… Show more
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