Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis

Stabholz, Adam; Soskolne, W. A.; Shapira, Lior

doi:10.1111/j.1600-0757.2010.00340.x

Cited by 240 publications

(243 citation statements)

References 196 publications

(225 reference statements)

Supporting

Mentioning

227

Contrasting

Unclassified

Order By: Relevance

“…Among the principal genetic variants pointed out from literature, 2,46 for the present study, we decided to focus our attention on the 28 candidate gene polymorphisms, located within 14 different genes, described in Table 2, and to investigate their relation with AgP susceptibility.…”

Section: Genotyping and Snps Selectionmentioning

confidence: 99%

“…1,2 Pathogenic bacteria constitute the primary extrinsic agent in the aetiology of AgP; however, the risk of developing periodontal disease is not the same for all individuals, suggesting that host factors are involved in determining susceptibility to the disease. 3,4 The role of genes and their variants in determining the host response in both 'chronic' and 'aggressive' forms of periodontitis, as well as in the progression of the disease, has been largely investigated.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 The role of genes and their variants in determining the host response in both 'chronic' and 'aggressive' forms of periodontitis, as well as in the progression of the disease, has been largely investigated. 2,5 As it is accepted that the immune system has an important role in the pathogenesis of periodontitis, most genes that are suggested to be responsible for the development of periodontitis are also linked to the immune response. These include genes that affect the expression of the interleukin (IL)-1, IL-6, tumour necrosis factor (TNF)-a and its receptors, IL-10, selenoprotein S, Fc-g receptor, CD14 molecule, toll-like receptors, caspase recruitment domain 15 and vitamin D receptor.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

et al. 2011

View full text Add to dashboard Cite

Aggressive periodontitis (AgP) is a multifactorial disease. The distinctive aspect of periodontitis is that this disease must deal with a large number of genes interacting with one another and forming complex networks. Thus, it is reasonable to expect that gene-gene interaction may have a crucial role. Therefore, we carried out a pilot case-control study to identify the association of candidate epistatic interactions between genetic risk factors and susceptibility to AgP, by using both conventional parametric analyses and a higher order interactions model, based on the nonparametric Multifactor Dimensionality Reduction algorithm. We analyzed 122 AgP patients and 246 appropriate periodontally healthy individuals, and genotyped 28 polymorphisms, located within 14 candidate genes, chosen among the principal genetic variants pointed out from literature and having a role in inflammation and immunity. Our analyses provided significant evidence for gene-gene interactions in the development of AgP, in particular, present results: (a) indicate a possible role of two new polymorphisms, within SEPS1 and TNFRSF1B genes, in determining host individual susceptibility to AgP; (b) confirm the potential association between of IL-6 and Fc g-receptor polymorphisms and the disease; (c) exclude an essential contribution of IL-1 cluster gene polymorphisms to AgP in our Caucasian-Italian population.

show abstract

Section: Genotyping and Snps Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Cigarettes have also been shown to be the major risk factor in the prevalence, extent, and severity of periodontal diseases. 3,4,5,6 Some studies have demonstrated the possible absorption of nicotine by the root surfaces of smokers with periodontal disease. 7,8 In addition, fibroblasts that were exposed to nicotine Naida Zanini ASSEM (a) Márcio Luiz Ferro ALVES (a) Alessandra Barreto LOPES (a) Erivan Clementino GUALBERTO JUNIOR (a) Valdir Gouveia GARCIA (b) Letícia Helena THEODORO …”

Section: Introductionmentioning

confidence: 99%

Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

et al. 2017

View full text Add to dashboard Cite

The aim of this study was to perform a systematic review and meta-analysis to examine the effect of systemic antibiotics in the periodontal treatment of smokers. The selection criteria were as follows: controlled randomized clinical trials; studies published in English; studies with smoker patients diagnosed with chronic periodontitis; patients without systemic diseases; studies that used systemic antibiotic therapy associated with periodontal treatment; studies that presented results for the test and control groups and assessments of clinical periodontal parameters, such as probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL). The differences in average weights were calculated with a confidence interval (CI) of 95% for PD reduction, CAL gain and BOP. The means of the periodontal clinical parameters were compared between the baseline and post-treatment periods between the test groups and the control groups. The heterogeneity was assessed using the Cochran Q test (Q (df = 3), α = 5%). A total of 67 articles were found, and after the selection process, three randomized controlled trials were included in the meta-analysis. The results indicate that SRP associated with systemic antibiotics promoted additional benefits when compared to SRP alone, with a greater reduction of PD (p = 0.0359, CI = -0.42, -0.01) and a gain of CAL (p = 0.0161, CI = -0.39, -0.04). There was a modest PD reduction (PD, DM -0.21) and a modest CAL gain (CAL, DM -0.22). The results of our meta-analysis reveal the clinical benefits of systemic antibiotics as an adjunct to the non-surgical periodontal treatment of smokers. These clinical improvements, although statistically significant, appeared to be of little clinical relevance.

show abstract

“…Risk factors identified for periodontal diseases are similar to the ones for chronic periodontitis and aggressive periodontitis (28) . These factors include: immunological host factors, ethnicity, microbiological factors, oral hygiene habits, age, gender, frequency of dental visits, demographic factors, smoking habits and psychological factors (29) .…”

Section: Risk Factorsmentioning

confidence: 63%

Diagnóstico y tratamiento de la periodontitis agresiva

Benza-Bedoya

Pareja-Vásquez

2017

Odontoestomatología

View full text Add to dashboard Cite

Aggressive periodontitis is a low-prevalence, multifactorial disease, of rapid progression and with no systemic compromise. It presents immunological alterations, a strong genetic influence, familial aggregation and early onset. It can be localized or generalized. It is not clear whether it is an independent periodontal disease, or if it is the phenotypic expression of chronic periodontitis in susceptible patients. Its diagnostic protocol includes a dental medical history, a clinical periodontal examination and a radiological examination. Treatment usually includes improving oral hygiene, dental scaling and root planing, as well as systemic and local antibiotic therapy. Surgical therapy will depend on each individual case. Maintenance therapy is essential to achieve better results. The aim of this paper is to review diagnostic and therapeutic protocols, and to propose a treatment flowchart based on the latest scientific evidence.

show abstract

Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis

Cited by 240 publications

References 196 publications

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

Gene–gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis

Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

Diagnóstico y tratamiento de la periodontitis agresiva

Contact Info

Product

Resources

About