Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore

Robien, Kim; Butler, Lesley M.; Wang, Renwei; Beckman, Kenneth B.; Walek, Dinesha; Koh, Woon Puay; Yuan, Jian‐Min

doi:10.1017/s0007114512001675

Cited by 78 publications

(102 citation statements)

References 59 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CYP2R1 encodes vitamin D hydroxylase which hydroxylates vitamin D at 25-C position for synthesis in liver [36]. In line with previous studies, we found the risk alleles of CYP2R1-rs10741657 and rs1993116 were marginally associated with lower serum levels of 25(OH)D without Bonferroni adjustments [14,18,19,23]. Indeed, in a genome-wide association study, Wang et al [19] found that CYP2R1-rs10741657 was significantly associated with 25(OH)D levels in 30,000 individuals of European descent from 15 cohorts.…”

Section: Serum 25(oh)d Vitamin D Status and Snps Of Vdr Gc And Cyp2r1supporting

confidence: 90%

“…The CYP2R1-rs12794714 is less investigated compared with other SNPs in previous studies. Two previous studies found that the risk allele of CYP2R1-rs12794714 was associated with lower levels of 25(OH)D [12,23]. The reason for non-significant association between CYP2R1-rs12794714 and serum levels of 25(OH)D in the present study is unknown.…”

Section: Serum 25(oh)d Vitamin D Status and Snps Of Vdr Gc And Cyp2r1contrasting

confidence: 64%

“…Bu et al [18] also found that the CYP2R1-rs10741657 was associated with serum levels of 25(OH)D among healthy Caucasian subjects. In addition, Robien et al [23] found that all these three SNPs were significantly associated with 25(OH)D concentration in Chinese. The CYP2R1-rs12794714 is less investigated compared with other SNPs in previous studies.…”

Section: Serum 25(oh)d Vitamin D Status and Snps Of Vdr Gc And Cyp2r1mentioning

confidence: 99%

“…Genetic variants of GC, including the GC-rs4588, rs7041, and rs2282679, have been widely investigated and reported to be associated with the levels of vitamin D across different populations [11,17,19,23,31]. In addition, rs12794714, rs10741657, and rs1993116 of CYP2R1, which maps on the chromosome 11p15.2, were also associated with the levels of vitamin D in previous studies [14,18,19,23]. Totally, 9 SNPs including VDR-rs2228570, rs1544410, rs731236, GC-rs4588, rs7041, rs2282679, CYP2R1-rs12794714, rs10741657and rs1993116, were materials and methods…”

Section: Snp Selection and Genotypingmentioning

confidence: 99%

“…Thus, genetic variants in the vitamin D metabolism pathway are widely investigated. Recently, genetic association studies including genome-wide association studies (GWAS) have identified that a majority of SNPs are associated with circulating levels of 25(OH) D and vitamin D deficiency [11,12,[16][17][18][19][20][21][22][23]. However, these genetic association studies are mainly conducted in Western populations, and it remains to be confirmed whether these genetic variants have similar effects in Chinese.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese

Yin

et al. 2014

Endocr J

View full text Add to dashboard Cite

Vitamin D status, measured by 25-hydroxyvitamin D [25(OH)D], is important for musculoskeletal and non-musculoskeletal health. Vitamin D deficiency has been related to rickets, diabetes mellitus, metabolic syndrome, hypertension, cardiovascular disease, and cancer [1][2][3][4][5][6]. Sun exposure, dietary and supplementary vitamin D intake, race, age, sex, obesity, skin color, and tea intake have been previously reported to be associated with circulating levels of 25(OH)D [7][8][9][10] Chinese. Nine common variants of VDR, GC and CYP2R1 were genotyped using multiple SNaPshot assay, and serum 25(OH)D was detected by radioimmunoassay. The prevalence of vitamin D deficiency (<50 nmol/L) was 38.8%, which is higher in women (46.2%) than in men (34.3%, P<0.0001). The risk alleles of three common variants of GC (rs7041, rs4588, and rs2282679) were significantly associated with a lower serum levels of 25(OH)D (-1.789 ≤β ≤-3.549, P ≤0.006), while common variants in VDR and CYP2R1 were not associated with serum levels of 25(OH)D after adjusted for covariates (P ≥0.30). None of the nine common variants were associated with the presence of vitamin D deficiency in multivariable adjusted logistic regression analyses (P ≥0.17). Haplotype-based analyses of GC-rs7041 and rs4588 showed that the haplotype Gc2-2 (rs7041 AA and rs4588 TT) had the lowest levels of 25(OH)D compared with other haplotypes that contained at least one copy of Gc1 allele (Ptrend <0.0001). Our results suggest that the common variants of GC are genetic determinants of serum 25(OH)D in Chinese.

show abstract

Section: Serum 25(oh)d Vitamin D Status and Snps Of Vdr Gc And Cyp2r1supporting

confidence: 90%

Section: Serum 25(oh)d Vitamin D Status and Snps Of Vdr Gc And Cyp2r1contrasting

confidence: 64%

Section: Serum 25(oh)d Vitamin D Status and Snps Of Vdr Gc And Cyp2r1mentioning

confidence: 99%

Section: Snp Selection and Genotypingmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese

Yin

et al. 2014

Endocr J

View full text Add to dashboard Cite

show abstract

Pharmacokinetic Drug Interaction Between Raloxifene and Cholecalciferol in Healthy Volunteers

Lee

Kang

Jung

et al. 2022

Clinical Pharm in Drug Dev

View full text Add to dashboard Cite

Osteoporosis is a common skeletal disorder, often leading to fragility fracture. Combination therapy with raloxifene, a selective estrogen receptor modulator,and cholecalciferol (vitamin D 3 ) has been proposed to improve the overall efficacy and increase compliance of raloxifene therapy for postmenopausal osteoporosis. To our knowledge, there has been no report of any study on the pharmacokinetic interaction between raloxifene and cholecalciferol. This study aimed to evaluate the possible pharmacokinetic interactions between raloxifene and cholecalciferol in healthy adult male Korean volunteers. Twenty subjects completed this open-label, randomized, single-dose, 3-period, 6-sequence, crossover phase 1 study with a 14-day washout period. Serial blood samples were collected from 20 hours before dosing to 96 hours after dosing. The plasma concentrations of raloxifene and cholecalciferol were determined using a validated method for high-performance liquid chromatography with tandem mass spectrometry. The geometric mean ratios (90%CIs) for area under the plasma concentration-time curve from time 0 to the last quantifiable time point and maximum plasma concentration of raloxifene with or without cholecalciferol were 1.02 (0.87-1.20) and 0.87 (0.70-1.08), respectively. For baseline-corrected cholecalciferol, geometric mean ratios (90%CIs) of area under the plasma concentration-time curve from time 0 to the last quantifiable time point and maximum plasma concentration with or without raloxifene were 1.01 (0.93-1.09) and 0.99 (0.92-1.06),respectively.Concurrent treatment with raloxifene and cholecalciferol was generally well tolerated. These results suggest that raloxifene and cholecalciferol have no clinically relevant pharmacokinetic drug-drug interactions when administered concurrently. All treatments were well tolerated, with no serious adverse events.

show abstract

Vitamin D and Its Relationship with Markers of Bone Metabolism in Healthy Asian Women

Tan

Saw

Sethi

2013

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore

Cited by 78 publications

References 59 publications

Serum 25(OH)D and vitamin D status in relation to <i>VDR</i>, <i>GC</i> and <i>CYP2R1</i> variants in Chinese

Serum 25(OH)D and vitamin D status in relation to <i>VDR</i>, <i>GC</i> and <i>CYP2R1</i> variants in Chinese

Pharmacokinetic Drug Interaction Between Raloxifene and Cholecalciferol in Healthy Volunteers

Vitamin D and Its Relationship with Markers of Bone Metabolism in Healthy Asian Women

Contact Info

Product

Resources

About