Genetic and environmental factors affecting peak bone mass in premenopausal Japanese women

Hayakawa, Yukihiro; Yanagi, Hisako; Hara, S.; Amagai, Hitoshi; Endo, Kazue; Hamaguchi, Hideo; Tomura, Shigeo

doi:10.1007/bf02897967

Cited by 3 publications

(4 citation statements)

References 27 publications

(27 reference statements)

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“…Table I shows further detailed information on the eligible studies. Two studies recruited subjects in Italy ( 20 , 21 ), one in Japan ( 30 ) and 12 in China. Three studies recruited only male subjects ( 21 , 24 , 26 ), one study recruited both male and female subjects ( 31 ) and 11 studies recruited only female subjects.…”

Section: Resultsmentioning

confidence: 99%

“…BMD measurements in all 15 studies were performed by DXA, although with different instruments. The BMD values of both the lumbar spine and femoral neck were measured in 14 of the studies, with one study measuring only the lumbar spine BMD ( 30 ). In three of the 15 eligible studies, the BMD value was adjusted for age and weight ( 16 , 20 , 21 ).…”

Section: Resultsmentioning

confidence: 99%

“…In three of the 15 eligible studies, the BMD value was adjusted for age and weight ( 16 , 20 , 21 ). Three of the studies had combined CT and TT data (indicated as CT/TT), without raw CT or TT data ( 22 , 24 , 30 ). Genotyping was carried out in a consistent manner across studies using validated polymerase chain reaction methods.…”

Section: Resultsmentioning

confidence: 99%

“…To clarify whether Alu I polymorphisms had an effect on lumbar spine BMD in a Chinese cohort, the studies recruiting subjects from countries other than China ( 20 , 21 , 30 ) were excluded. In Chinese male and female subjects, those with the CC genotype had a higher BMD than those with the CT genotype.…”

Section: Resultsmentioning

confidence: 99%

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Association between calcitonin receptor AluI gene polymorphism and bone mineral density: A meta-analysis

Xiong

Xin

Zhang

et al. 2014

Experimental and Therapeutic Medicine

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The association between calcitonin receptor (CTR) AluI gene polymorphism and bone mineral density (BMD) remains unclear. In order to elucidate this association, a meta-analysis was performed to provide a comprehensive assessment of the studies carried out to date. PubMed, the Cochrane Library, Web of Science and the China National Knowledge Infrastructure database were searched to identify eligible studies. The data were extracted independently by two authors using a standard form, the studies were meta-analyzed and disagreements were resolved through discussion. Fifteen eligible studies involving 3,093 females and 654 males were included for analysis. Overall, the male subjects with the CC genotype had non-statistically different lumbar spine and femoral neck BMD compared to subjects with the CT/TT and CT genotypes. The BMD of female subjects with the CC genotype was similar to that of patients with the CT or CT/TT genotypes. In Chinese male subjects, those with the CC genotype had almost the same BMD as those with the CT and CT/TT genotypes. The results also demonstrated that Chinese female subjects with the CC genotype had similar BMD at the lumbar spine and femoral neck to subjects with the CT and CT/TT genotypes. Furthermore, Southern Chinese subjects with CC genotypes did not have a different BMD at the lumbar spine and femoral neck compared to patients with CT and CT/TT genotypes. Notably, Northern Chinese subjects with the CC genotype had a higher BMD at the lumbar spine compared to subjects with CT/TT genotypes and a lower BMD at the femoral neck compared to subjects with CT/TT genotypes. Among Northern Chinese females, those with CC genotypes also had a higher BMD at the lumbar spine compared to those with CT/TT genotypes, while no difference was observed in the BMD of the lumbar spine and femoral neck between patients with CC and CT genotypes. In Southern Chinese females, no significant difference was found in the BMD at the lumbar spine and femoral neck between those with CC and those with CT or CT/TT genotypes. In conclusion, the AluI gene polymorphism may have an association with BMD in Northern Chinese subjects and the CC genotype may have a protective effect on spine BMD; however, the CC genotype may be a risk factor for low femoral neck BMD in Northern Chinese subjects. Further studies are required to fully investigate the potential association between AluI gene polymorphism and BMD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Association between calcitonin receptor AluI gene polymorphism and bone mineral density: A meta-analysis

Xiong

Xin

Zhang

et al. 2014

Experimental and Therapeutic Medicine

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Effects of the Cdx-2 Polymorphism of the Vitamin D Receptor Gene and Lifestyle Factors on Bone Mineral Density in a Representative Sample of Japanese Women: The Japanese Population-based Osteoporosis (JPOS) Study

et al. 2005

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Using a large-scale representative sample of the Japanese female population, we examined the effects of a single nucleotide polymorphism within a binding site of Cdx-2 in the promoter region of the vitamin D receptor gene on bone mineral density (BMD), and the interactions between this polymorphism and lifestyle factors on BMD. Fifty women were randomly selected from each of the 5-year age-stratified populations (15-79 years) in each of three chosen municipalities as a part of the Japanese Population-based Osteoporosis Study. BMD at the lumbar spine, hip, and distal forearm was measured using dual-energy X-ray absorptiometry at baseline and again in a follow-up study conducted 3 years later. Information on lifestyle factors was collected in a questionnaire and followed up in interviews. The G-to-A polymorphism within the Cdx-2 binding site was determined by a TaqMan allelic discrimination assay. At baseline, 1,340 women were analyzed. The baseline BMD in the ultradistal forearm in premenopausal women with the GG genotype was significantly lower than in those with other genotypes. There was no association between the Cdx-2 genotype and the change in BMD at any of the skeletal sites. We found significant associations between daily milk consumption and baseline BMD at some skeletal sites but only in subjects with the GG genotype. In conclusion, the Cdx-2 polymorphism alone did not have a substantial effect on BMD in Japanese women. However, this polymorphism might have some effect in women with low calcium intake.

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Prediction of bone mineral density from vitamin D receptor polymorphisms is uncertain in representative samples of Japanese Women. The Japanese Population-based Osteoporosis (JPOS) Study

Morita

Iki²,

Dohi³

et al. 2004

International Journal of Epidemiology

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Genetic and environmental factors affecting peak bone mass in premenopausal Japanese women

Cited by 3 publications

References 27 publications

Association between calcitonin receptor AluI gene polymorphism and bone mineral density: A meta-analysis

Association between calcitonin receptor AluI gene polymorphism and bone mineral density: A meta-analysis

Effects of the Cdx-2 Polymorphism of the Vitamin D Receptor Gene and Lifestyle Factors on Bone Mineral Density in a Representative Sample of Japanese Women: The Japanese Population-based Osteoporosis (JPOS) Study

Prediction of bone mineral density from vitamin D receptor polymorphisms is uncertain in representative samples of Japanese Women. The Japanese Population-based Osteoporosis (JPOS) Study

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