Genetic and Environmental Effects on Urinary Kallikrein, Catecholamines, Sodium, Potassium, Urea Nitrogen and Inorganic Sulfate Sulfur Levels in School-Age Twins

Kagamimori, Sadanobu; Naruse, Yuchi; Matsubara, Ikuo; Fu, Bi Li; Sokejima, Shigeru; Yamagami, Takashi

doi:10.1159/000154317

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…A second study of 30 matched stone formers and controls did not find a difference in total excretion [18]. In addition, a twin study suggested that urinary sulfate levels are determined largely by environment, rather than genetics [19].…”

Section: Discussionmentioning

confidence: 92%

Sulfate but Not Thiosulfate Reduces Calculated and Measured Urinary Ionized Calcium and Supersaturation: Implications for the Treatment of Calcium Renal Stones

et al. 2014

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BackgroundUrinary sulfate (SO4 2−) and thiosulfate (S2O3 2−) can potentially bind with calcium and decrease kidney stone risk. We modeled the effects of these species on the concentration of ionized calcium (iCa) and on supersaturation (SS) of calcium oxalate (CaOx) and calcium phosphate (CaP), and measured their in vitro effects on iCa and the upper limit of stability (ULM) of these salts.MethodsUrine data from 4 different types of stone patients were obtained from the Mayo Nephrology Clinic (Model 1). A second data set was obtained from healthy controls and hypercalciuric stone formers in the literature who had been treated with sodium thiosulfate (STS) (Model 2). The Joint Expert Speciation System (JESS) was used to calculate iCa and SS. In Model 1, these parameters were calculated as a function of sulfate and thiosulfate concentrations. In Model 2, data from pre- and post STS urines were analyzed. ULM and iCa were determined in human urine as a function of sulfate and thiosulfate concentrations.ResultsCalculated iCa and SS values for all calcium salts decreased with increasing sulfate concentration. Thiosulfate had no effect on these parameters. In Model 2, calculated iCa and CaOx SS increased after STS treatment, but CaP SS decreased, perhaps due to a decrease in pH after STS treatment. In confirmatory in vitro experiments supplemental sulfate, but not thiosulfate, significantly increased the calcium needed to achieve the ULM of CaP and tended to increase the oxalate needed to reach the ULM of CaOx. Sulfate also significantly decreased iCa in human urine, while thiosulfate had no effect.ConclusionIncreasing urinary sulfate could theoretically reduce CaOx and CaP stone risk. Although STS may reduce CaP stone risk by decreasing urinary pH, it might also paradoxically increase iCa and CaOx SS. As such, STS may not be a viable treatment option for stone disease.

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Section: Discussionmentioning

confidence: 92%

Sulfate but Not Thiosulfate Reduces Calculated and Measured Urinary Ionized Calcium and Supersaturation: Implications for the Treatment of Calcium Renal Stones

et al. 2014

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“…They also reported that diminished response of renal TK excretion to orally administered KCl is demonstrated in African-Americans compared with white [18]. In another study, hereditary factors affect on urinary K + , Na + and TK excretion in Japanese by a genetic analysis of 35 pairs of monozygotic twins and 19 pairs of dizygotic twins in school children [19].…”

Section: Introductionmentioning

confidence: 96%

Intracellular Ca2+ contributes to K+-induced increase in renal kallikrein secretion

Fujita

Ogino

Daigo

et al. 2006

International Immunopharmacology

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Dissecting the genetic architecture of the cardiovascular and renal stress response

Snieder

Harshfield

Barbeau

et al. 2002

Biological Psychology

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Genetic and Environmental Effects on Urinary Kallikrein, Catecholamines, Sodium, Potassium, Urea Nitrogen and Inorganic Sulfate Sulfur Levels in School-Age Twins

Cited by 7 publications

References 13 publications

Sulfate but Not Thiosulfate Reduces Calculated and Measured Urinary Ionized Calcium and Supersaturation: Implications for the Treatment of Calcium Renal Stones

Sulfate but Not Thiosulfate Reduces Calculated and Measured Urinary Ionized Calcium and Supersaturation: Implications for the Treatment of Calcium Renal Stones

Intracellular Ca2+ contributes to K+-induced increase in renal kallikrein secretion

Dissecting the genetic architecture of the cardiovascular and renal stress response

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