Genetic and clinical risk factors of root resorption associated with orthodontic treatment

Guo, Yifan; He, Shushu; Gu, Tian; Liu, Yi; Chen, Song

doi:10.1016/j.ajodo.2015.12.028

Cited by 46 publications

(40 citation statements)

References 38 publications

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“…In this regard, linear regression analysis was adopted in most previous studies, in which all variables are treated as fixed effects. However, host factors, such as single-nucleotide polymorphisms in interleukin-6, also affect ARR, 10 which means that individual orthodontic patients may respond differently to the same treatment modality. A mixed-effects model can treat subjects as a random effect; thus, it is preferred over traditional statistical approaches for investigating risk factors of ARR.…”

Section: Introductionmentioning

confidence: 99%

Apical root displacement is a critical risk factor for apical root resorption after orthodontic treatment

Kim

Lee

et al. 2018

The Angle Orthodontist

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Objectives: To identify risk factors for apical root resorption (ARR) of maxillary and mandibular incisors using mathematical quantification of apical root displacement (ARD) and multiple linear mixed-effects modeling. Materials and Methods: Periapical radiographs of maxillary and mandibular incisors and lateral cephalograms of 135 adults were taken before and after orthodontic treatment. ARR was measured on the periapical radiographs, and movement of central incisors was evaluated on the superimposed pre-and posttreatment lateral cephalograms. ARD was mathematically calculated from pretreatment tooth length, inclination change, and movement of the incisal edge. Linear mixed-effects model analysis was performed to identify risk factors for ARR, and standardized coefficients (SCs) were calculated to investigate the relative contribution of the risk factors to ARR. Results: Vertical ARD showed the highest SCs for both maxillary and mandibular incisors. Horizontal ARD showed the second highest SC for mandibular incisors but was not significantly correlated with the ARR of maxillary incisors. When horizontal and vertical ARDs were included in the mixed-effects model, the use of self-ligating brackets was significantly correlated with increased ARR of mandibular incisors. Conclusions: ARD is a critical factor for ARR after orthodontic treatment. Careful monitoring of ARR is recommended for patients requiring significant ARD of incisors. (Angle Orthod. 2018;88:740-747.)

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Section: Introductionmentioning

confidence: 99%

Apical root displacement is a critical risk factor for apical root resorption after orthodontic treatment

Kim

Lee

et al. 2018

The Angle Orthodontist

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“…One potential explanation for such diversity in the results is genetic predisposition. Hartsfield et al (2009)(9) and Guo et al (2015) (8) show that patients with a specific genotype have a higher risk of root resorption during orthodontic treatment. Differences in results can also be explained by the various methods used among research to measure root resorption, and the precision of these methods.…”

Section: Resultsmentioning

confidence: 99%

“…Despite these methods being broadly used, they lack precision in diagnostics, with the reason differing for each radiological method: image magnification and distortion, superimposition of different structures, and incorrect patient positioning, respectively (12,6). Root resorption is a three-dimensional (3D) process; it cannot be adequately evaluated by conventional 2D radiographic methods (8). With the introduction of cone beam computer tomography (CBCT) to dental practice, it has been possible to evaluate structures in 3D.…”

Section: Introductionmentioning

confidence: 99%

“…Compared to 2D radiographic methods e.g. periapical radiograph, it is possible to make linear measures more precisely with CBCT, including measuring the length of the root (12,8). The objectives of this study were to 1) evaluate root resorption before and after orthognathic Le Fort I surgery, 2) analyse the correlation of treatment duration with root resorption, 3) analyse the correlation of crown-root ratio with root resorption, and 4) analyse the correlation of the severity of dentofacial deformity (Wits appraisal, ANB angle, and overjet) with root resorption.…”

Section: Introductionmentioning

confidence: 99%

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Apical Resorption of Upper Incisors and Canines During Orthodontic Treatment in Class III Orthognathic Surgery Patients – a Longitudinal Cone Beam Computer Tomography Study

Gavare

Urtane

Jakobsone

et al. 2017

Acta Chirurgica Latviensis

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Summary Introduction. Although severe root resorption is rare, it is a side effect of orthodontic treatment which affects tooth prognosis. Patients with severe dentofacial deformity, for whom orthodontic treatment and orthognathic surgery was done at the age of 18 and later, had long duration orthodontic treatment and orthognathic surgery, and are at a high risk of root resorption. The impact of orthognathic surgery on root resorption has not been sufficiently studied, and therefore is an interesting topic to research. Aim of the Study. To identify the risk factors for apical root resorption of maxillary incisors and canines as a result of orthodontic and surgical treatment of Class III malocclusion involving LeFort I osteotomy. Material and methods. The root lengths of upper incisors and canines were measured on cone beam computer tomography (CBCT) scans obtained from a database of orthognathic surgery patients. As a criteria for root resorption was chosen the difference in root lengths between different time points. The measurements were performed using the scans taken before orthodontic treatment (T1), before surgery (T2), and after post surgery orthodontic treatment (T3), of 28 subjects, aged 20.5 ± 3.81 years, with the mean presurgery treatment time of 19.9 ± 8.8 months, and post-surgery time of 7.1 ± 3.1 months. Changes in root lengths during different time spans were correlated with treatment duration, the initial crown/root ratio, and the severity of dentofacial deformity (Wits appraisal, ANB angle, and overjet). Results. During T1 - T2 the roots of the lateral incisors shortened by a maximum of 0.78 ± 0.83 mm (p < 0.001), at a rate of 0.04 mm per month. During T2 - T3 the lengths of the central incisor roots decreased most by 0.49 ± 0.52 (p < 0.001) at a rate of 0.07 mm per month. The resorption speed for canines increased from 0.03 mm to 0.1 mm per month before and after surgery. There were statistically significant correlations between the crown-root ratio and the incisor root length (r = 0.319 for lateral and r = 303 for central, both p<0,05) and for canines (r = 482, p<0.01). The associations between the shortened root length, in different time spans for different teeth, and the severity of malocclusion were inconsistent. Conclusions. Overall, the shortened root length during combined orthodontic and surgical treatment might not be clinically significant. After surgery, the rate of root resorption (mm per month) increased, especially for canines. The teeth with initially shorter roots showed more resorption during treatment.

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“…[46] This last study is a good example of how the relative frequency of polymorphic alleles for a specific SNP among different ethnic groups may affect the outcome of studies and hamper their comparison. In summary support for treatment related risk factors has varied amongst studies, with a longer of treatment being associated with increased likelihood of EARR being the most consistent.…”

Section: Genetic Influence In Earr and Its Biological Scenariomentioning

confidence: 99%

Bone Density and Dental External Apical Root Resorption

Iglesias-Linares

Morford

Hartsfield

2016

Curr Osteoporos Rep

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When orthodontic patients desire shorter treatment times with aesthetic results and long-term stability, it is important for the orthodontist to understand the potential limitations and problems that may arise during standard and/or technology-assisted accelerated treatment. Bone density plays an important role in facilitating orthodontic tooth movement (OTM), such that reductions in bone density can significantly increase movement velocity. Lifestyle, genetic background, environmental factors and disease status all can influence a patients’ overall health and bone density. In some individuals, these factors may create specific conditions that influence systemic-wide bone metabolism. Both genetic variation and the onset of a bone-related disease can influence systemic bone density and local bone density, such as is observed in the mandible and maxilla. These types of localized density changes can affect the rate of OTM and may also influence the risk of unwanted outcomes, i.e., the occurrence of dental external apical root resorption (EARR).

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Genetic and clinical risk factors of root resorption associated with orthodontic treatment

Cited by 46 publications

References 38 publications

Apical root displacement is a critical risk factor for apical root resorption after orthodontic treatment

Apical root displacement is a critical risk factor for apical root resorption after orthodontic treatment

Apical Resorption of Upper Incisors and Canines During Orthodontic Treatment in Class III Orthognathic Surgery Patients – a Longitudinal Cone Beam Computer Tomography Study

Bone Density and Dental External Apical Root Resorption

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