Genetic and Biological Properties of Original TBEV Strains Group Circulating in Eastern Siberia

Abstract

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Tick‐borne encephalitis virus subtypes emerged through rapid vector switches rather than gradual evolution

“…, ; Kozlova et al. ) (Table S1). Proceeding from the above, it could be hypothesized that new variants of TBEV have to be found in this area.…”

“…Moreover, the unique strain 178-79, found in the same area, is also likely to be a transition form. Genetic features of these strains are specific enough to allow some researchers to propose them as fifth and fourth TBEV subtypes, respectively (Demina et al 2010(Demina et al , 2012Kozlova et al 2013) (Table S1). Proceeding from the above, it could be hypothesized that new variants of TBEV have to be found in this area.…”

“…Phylogenetic analysis revealed three subtypes of TBEV, with 15.2-16.4% and 6.2-6.9% differences on nucleotide and amino acid level, respectively (Kozlova et al 2013). European subtype (TBEV-Eu) is widely distributed in Europe and the European part of Russia (Ecker et al 1999;Lundkvist et al 2001;Haglund et al 2003) while Far Eastern (TBEV-FE) and Siberian (TBEV-Sib) subtypes are spread from Japan and the Far East of Russia to the Baltic countries (Lundkvist et al 2001;Mickiene et al 2001;Jaaskelainen et al 2006).…”

“…Phylogenetic analysis revealed three subtypes of TBEV, with 15.2–16.4% and 6.2–6.9% differences on nucleotide and amino acid level, respectively (Kozlova et al. ). European subtype (TBEV‐Eu) is widely distributed in Europe and the European part of Russia (Ecker et al.…”

“…Each TBEV subtype is characterized by a specific amino acid signature of the E protein that is used for classification purposes (Ecker et al 1999). Besides three conventional subtypes, 178-79 and "886-84 group" strains are proposed to fourth and fifth TBEV subtypes, respectively (Demina et al 2010(Demina et al , 2012Kozlova et al 2013).…”