Genetic analysis of X-linked hybrid sterility in the house mouse

Storchová, Radka; Gregorová, Soňa; Buckiová, Daniela; Kyselová, Vendula; Divina, Petr; Forejt, Jiřı́

doi:10.1007/s00335-004-2386-0

Cited by 142 publications

(226 citation statements)

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“…In hybrid males, sterility is more common when M. m. musculus is the mother (Britton-Davidian et al 2005;Good et al 2008b;Vyskočilová et al 2009). The role for the M. m. musculus X chromosome suggested by these observations has been confirmed through backcrosses (Storchová et al 2004) and chromosomal introgression studies (Good et al 2008a;Gregorová et al 2008). Reduced gene flow of X-linked loci across the hybrid zone (Tucker et al 1992;Dod et al 1993;Munclinger et al 2002;Payseur et al 2004;Dod et al 2005;Macholán et al 2007) raises the possibility that this chromosome also confers hybrid male sterility in natural populations.…”

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confidence: 83%

“…In addition, M. m. musculus and M. m. domesticus exhibit prezygotic isolation, including preferences for mates from the same subspecies (Laukaitis et al 1997;Talley et al 2001;Ganem 2002, 2005;Smadja et al 2004;Ganem et al 2008) and higher fertilization rates by sperm from the same subspecies when females are multiply mated (Dean and Nachman 2009). The most direct evidence for reproductive isolation comes from laboratory crosses involving wild-derived inbred strains, where F 1 hybrid male sterility is routinely observed, usually without hybrid female sterility (Iványi et al 1969;Forejt and Iványi 1974;Storchová et al 2004;BrittonDavidian et al 2005;Vyskočilová et al 2005Vyskočilová et al , 2009Good et al 2008a,b).…”

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confidence: 99%

“…Substantial effort directed toward finding the incompatibilities that underlie hybrid male sterility between M. m. domesticus and M. m. musculus has revealed some genetic patterns. First, the X chromosome is an important contributor (Oka et al 2004;Storchová et al 2004;Britton-Davidian et al 2005;Good et al 2008aGood et al ,b, 2010Vyskočilová et al 2009). F 1 's from most crosses follow Haldane's rule (Haldane 1922), with hybrid females showing few signs of sterility.…”

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confidence: 99%

“…At least four regions of the M. m. musculus X chromosome cause sterile phenotypes when introgressed onto a M. m. domesticus genomic background (Good et al 2008a). Furthermore, genetic mapping in multiple crosses suggests that interactions involving several segments of the X chromosome are required to generate hybrid male sterility (Oka et al 2004;Storchová et al 2004).…”

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confidence: 99%

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Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice

et al. 2011

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Reproductive isolation between species is often caused by deleterious interactions among loci in hybrids. Finding the genes involved in these incompatibilities provides insight into the mechanisms of speciation. With recently diverged subspecies, house mice provide a powerful system for understanding the genetics of reproductive isolation early in the speciation process. Although previous studies have yielded important clues about the genetics of hybrid male sterility in house mice, they have been restricted to F 1 sterility or incompatibilities involving the X chromosome. To provide a more complete characterization of this key reproductive barrier, we conducted an F 2 intercross between wild-derived inbred strains from two subspecies of house mice, Mus musculus musculus and Mus musculus domesticus. We identified a suite of autosomal and X-linked QTL that underlie measures of hybrid male sterility, including testis weight, sperm density, and sperm morphology. In many cases, the autosomal loci were unique to a specific sterility trait and exhibited an effect only when homozygous, underscoring the importance of examining reproductive barriers beyond the F 1 generation. We also found novel two-locus incompatibilities between the M. m. musculus X chromosome and M. m. domesticus autosomal alleles. Our results reveal a complex genetic architecture for hybrid male sterility and suggest a prominent role for reproductive barriers in advanced generations in maintaining subspecies integrity in house mice.

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confidence: 83%

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confidence: 99%

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confidence: 99%

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Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice

et al. 2011

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“…Genetic studies in Drosophila demonstrated an excess of hybrid sterility loci on the X chromosome, a phenomenon referred to as Flarge X-effect_ (Orr & Coyne 1989, Tao et al 2003. Several X-linked hybrid sterility loci were also reported in mice (Oka et al 2004, Storchova et al 2004. These genetic studies suggest that hybrid sterility might be caused by incompatibility of multiple loci (or genes).…”

Section: Implications Of X-linked Meiosis Factorsmentioning

confidence: 99%

The role of spermatogonially expressed germ cell-specific genes in mammalian meiosis

Wang

Pan

2007

Chromosome Res

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Meiosis, a hallmark of sexual reproduction, reduces the chromatin complement by half to cope with genome doubling at fertilization and permits exchange of genetic material between parental genomes. Recent functional studies of novel proteins have greatly enhanced our understanding of the regulation of meiosis. The unique status of sex chromosomes in the male germ line may have shaped their content of germ line-intrinsic genes during evolution. Previously, a unique set of 36 spermatogonially expressed, mouse germ cell-specific genes was identified in one genomic screen. Thirteen of these genes have been disrupted in mice and two-thirds of these mouse mutants exhibit meiotic defects. Therefore, we hypothesize that the majority of uncharacterized germ cellspecific genes identified in the same screen, including 11 X-linked genes, might also play important roles in meiosis. In particular, we cite previously unpublished studies demonstrating that the NXF2 protein, an X-encoded factor, is present in early spermatocytes.

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Genetic loci affecting body weight and fatness in a C57BL/6J × PWK/PhJ mouse intercross

2007

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To determine the genetic variation that contributes to body composition in the mouse, we interbred a wild-derived strain (PWK/PhJ; PWK) with a common laboratory strain (C57BL/6J; B6). The parental, F 1 , and F 2 mice were phenotyped at 18 weeks old for body weight and composition using dual-energy X-ray absorptiometry (DEXA). A total of 479 (244 male and 235 female) F 2 mice were genotyped for 117 polymorphic markers spanning the autosomes. Twenty-eight suggestive or significant linkages for four traits (body weight, adjusted lean and fat weight, and percent fat) were detected. Of these, three QTLs were novel: one on the proximal portion of Chr 5 for body weight (Bwq8; LOD = 4.7), one on Chr 3 for lean weight (Bwtq13; LOD = 3.6), and one on Chr 11 for percent fat (Adip19; LOD = 5.8). The remaining QTLs overlapped previously identified linkages, e.g., Adip5 on Chr 9. One QTL was sex-specific (present in males only) and seven were sex-biased (more prominent in one sex than the other). Most alleles that increased body weight were contributed by the B6 strain, and most alleles that increased percent fat were contributed by the PWK strain. Eight pairs of interacting loci were identified, none of which exactly overlapped the main-effect QTLs. Many of the QTLs found in the B6 × PWK cross map to the location of previously reported linkages, suggesting that some QTLs are common to many strains (consensus QTLs), but three new QTLs appear to be particular to the PWK strain. The location and type of QTLs detected in this new cross will assist in future efforts to identify the genetic variation that determines the ratio of lean to fat weight as well as body size in mice.

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Genetic analysis of X-linked hybrid sterility in the house mouse

Cited by 142 publications

References 28 publications

Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice

Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice

The role of spermatogonially expressed germ cell-specific genes in mammalian meiosis

Genetic loci affecting body weight and fatness in a C57BL/6J × PWK/PhJ mouse intercross

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