Genetic Analysis of the S1 Gene of 4/91 Type Infectious Bronchitis Virus Isolated in Japan

Shimazaki, Yohko; Watanabe, Yuuko; Harada, Makiko; Seki, Yoshihisa; Kuroda, Yorifumi; Fukuda, Masaharu; Honda, Eiichi; Suzuki, Shinichi; Nakamura, Shigeyuki

doi:10.1292/jvms.71.583

Cited by 17 publications

(20 citation statements)

References 21 publications

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“…Three amino acids at positions 95, 508 and 530 were different between a UK/4/91 field isolate (4/91 pathogenic) and its embryo-passaged, attenuated derivative (4/91 vaccine) (Cavanagh et al, 2005). Interestingly, TA03 shared the same three amino acids with the 4/91 pathogenic strain, even though these changes are not associated with pathogenicity (Shimazaki et al, 2009). It has been suggested that replication of 4/91 strains in chickens and embryonated eggs is associated with position 95, particularly alanine in the vaccine strain and serine in the chickpassaged strain (Cavanagh et al, 2005).…”

Section: Discussionmentioning

confidence: 98%

“…The spreading of a virus from one area to another could be due, at least in part, by the illegal trading of chickens or by the use of attenuated vaccines. Recently, wild birds have been of concern as natural IBV carriers, since infected birds carry the viruses from one area to another (Cavanagh, 2007;Liu et al, 2005;Shimazaki et al, 2009;Sun et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

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A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China

Han

Sun

Yan

et al. 2011

Infection, Genetics and Evolution

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A comprehensive study of the epidemiology and pathogenicity of infectious bronchitis virus (IBV) in China was carried out by molecular characterization of the S1 gene from 46 isolates obtained for this study and 174 reference strains isolated over a 15-year period. Nine types were found according to sequence analysis and phylogenetic study of the S1 gene. The co-circulation of multiple IBV types and the ongoing emergence of IBV variants are the epidemiological challenges in China. Factors contributing to the continual emergence include mutations, insertions and deletions in the S1 protein genes; recombination between local IBV strains circulating in chicken flocks in China; and recombination between local strains and vaccine strains. Vaccination-challenge analysis between circulating field strains and Mass-type H120 vaccine indicated the need to develop new vaccines from local IBV strains. These results also emphasize the importance of continued IBV surveillance in China.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China

Han

Sun

Yan

et al. 2011

Infection, Genetics and Evolution

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“…The values with different letters are significantly different (P<0.05) (Cavanagh 2003(Cavanagh , 2007Kameka et al 2014). However, the emergence of new IBV variants, which led to infectious bronchitis outbreaks in vaccinated flocks, resulted in significant production losses (Xu et al 2007;Shimazaki et al 2009;Kameka et al 2014). Therefore, a novel approach that could be used as an alternative to, or in addition to, the existing means of control is urgently needed.…”

Section: Avbd5mentioning

confidence: 99%

Differential modulation of avian β-defensin and Toll-like receptor expression in chickens infected with infectious bronchitis virus

Zhang

et al. 2015

Appl Microbiol Biotechnol

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The host innate immune response either clears invading viruses or allows the adaptive immune system to establish an effective antiviral response. In this study, both pathogenic (passage 3, P3) and attenuated (P110) infectious bronchitis virus (IBV) strains were used to study the immune responses of chicken to IBV infection. Expression of avian β-defensins (AvBDs) and Toll-like receptors (TLRs) in 16 tissues of chicken were compared at 7 days PI. The results showed that P3 infection upregulated the expression of AvBDs, including AvBD2, 4, 5, 6, 9, and 12, while P110 infection downregulated the expression of AvBDs, including AvBD3, 4, 5, 6, and 9 in most tissues. Meanwhile, the expression level of several TLRs showed a general trend of upregulation in the tissues of P3-infected chickens, while they were downregulated in the tissues of P110-infected chickens. The result suggested that compared with the P110 strain, the P3 strain induced a more pronounced host innate immune response. Furthermore, we observed that recombinant AvBDs (including 2, 6, and 12) demonstrated obvious anti-viral activity against IBV in vitro. Our findings contribute to the proposal that IBV infection induces an increase in the messenger RNA (mRNA) expression of some AvBDs and TLRs, which suggests that AvBDs may play significant roles in the resistance of chickens to IBV replication.

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“…These vaccines use IBV strains such as Massachusetts, Connecticut and Arkansas and combinations thereof providing protection against almost all field strains of IBV. However, emergence of new variant more heterogeneous IBV strains (Cavanagh, 2003), leads to infectious bronchitis outbreaks in vaccinated flocks leading to significant production losses (Shimazaki et al, 2009;Xu et al, 2007). Therefore a novel approach that could be used as an alternative or additional to the existing means of control is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens

et al. 2014

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Infectious bronchitis virus (IBV) replicates in the epithelial cells of trachea and lungs of chicken, however the mechanism of generation of innate immune response against IBV infection in these tissues has not been fully characterized. Our objective was to study innate responses induced early following IBV infection in chickens. Initiation of the transcription of selected innate immune genes such as TLR3, TLR7, MyD88, IL-1β and IFN-β, as well as recruitment of macrophages, were evident following an initial down regulation of some of the observed genes (TLR3, IL-1β, and IFN-γ) in trachea and lung. This initial down-regulation followed by the induction of innate immune response to IBV infection appears to be inadequate for the control of IBV genome accumulation and consequent histopathological changes in these tissues. Potential induction of innate immunity before infection occurs may be necessary to reduce the consequences since vaccine induced immunity is slow to develop.

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Genetic Analysis of the S1 Gene of 4/91 Type Infectious Bronchitis Virus Isolated in Japan

Abstract: ABSTRACT. S1 gene sequences for infectious bronchitis virus (IBV) strains of the 4/91 genotype (commonly called 793B) isolated from field outbreaks in Japan were analyzed to ascertain the relationship to 4/91 vaccine strain.

Cited by 17 publications

References 21 publications

A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China

A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China

Differential modulation of avian β-defensin and Toll-like receptor expression in chickens infected with infectious bronchitis virus

Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens

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