Genetic analysis of physiological homeostasis: glomerular filtration rate following saline loading in mice

Abstract

Saline loading caused an increase in glomerular filtration rate in RAP mice but not in CBA mice. On the basis of progeny testing of F 2 hybrids, backcrosses to CBA, and inbred lines derived from backcrosses to RAP, it was concluded that the difference between the strains RAP and CBA was probably largely accounted for by a single gene locus. The use of this gene in physiological investigations of the control of glomerular filtration rate is suggested.

The Forms, Uses and Significance of Genetic Variation in Endocrine Systems

“…I n some organisms, particularly Duosophila, special staining techniques allow chromosomal aberrations to be identified, and their phenotypic effects followed through several generations. Some of the problems which can arise when characters show nongenetic correlations within a genetically uniform stock, and when there are more than two characters, have been discussed elsewhere (Shire, 1970;Stewart, 1971 ;Stewart & Mowbray, 1972;Ciaranello et al, 1974~).…”

Genetics and Biology: A Comment on the Significance of the Elston-Stewart Algorithm

“…Consequently, on this alternative view, genet ics per se is seen as having only minimal con tent; genetic variation is significant to the ex act extent that it influences biological organi zation, so that in order to perceive its significance the other biological disciplines arc absolutely indispensable. However, since 13 genetic variation can influence virtually every aspect and level of biological organization, from cell lineages [32] to ecological popula tions, this 'empty genetics' nevertheless plays a 'central' role in the sense that it provides for a meaningful articulation between the various biological disciplines -thus counteracting an other unfortunate modern tendency, that of the fragmentation of biology into a multitude of disconnected subspecialties.…”