Genetic analysis of mitomycin C-induced interchange in drosophila melanogaster females

Walker, V

doi:10.1016/0165-1218(75)90124-x

Cited by 2 publications

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“…It operates by cross-linking the complementary strands of DNA and may cause chromosome aberrations [6]. In Dro sophila, mitomycin C increases the frequency of crossing-over [27], of recessive mutations [28], and of chromosome aberrations [29]. It should therefore be able to induce tumoral transformation of somatic cells.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Inhibition of Nucleic Acids and Protein Synthesis upon the Development of Melanotic Tumors in <i>Drosophila</i>

Ghelelovitch¹

1983

Pathobiology

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Ethidium bromide and chloramphenicol which inhibit the synthesis of DNA and of proteins in mitochondria, respectively, are devoid of any important effect on the development of melanotic tumors in Drosophila. Mitomycin C, added to the food of larvae carrying the tu^48amutant gene, increases the number and the size of tumors. It is effective only if the treatment is begun long before the appearance of the tumors and acts probably by weakening the defence reactions of the host. Actinomycin D, an inhibitor of RNA synthesis, increases the number of tumors most effectively if administered at the time of tumor gene activity. Cycloheximide, which is known to inhibit protein synthesis on cytoplasmic ribosomes, is effective during the entire larval life and increases the number of tumors. The results suggest that the melanotic tumor development in Drosophila is linked to the loss of cellular functions rather than to the acquisition of new ones.

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Section: Discussionmentioning

confidence: 99%

Effect of the Inhibition of Nucleic Acids and Protein Synthesis upon the Development of Melanotic Tumors in <i>Drosophila</i>

Ghelelovitch¹

1983

Pathobiology

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“…One in male germ cells (Graf and Wurgler, 1982) and one in immature oocytes (Walker and Williamson, 1975). Unfortunately, the mechanism(s) leading to the elimination of the chromosome from the Drosophila germ cells is (are) not known.…”

Section: Genotoxic Effects In Yeastmentioning

confidence: 99%

Reversible inhibition of mammalian tubulin assembly in vitro and effects in Saccharomyces cerevisiae D61.M by mitomycin C

1989

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Genetic analysis of mitomycin C-induced interchange in drosophila melanogaster females

Cited by 2 publications

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Effect of the Inhibition of Nucleic Acids and Protein Synthesis upon the Development of Melanotic Tumors in <i>Drosophila</i>

Effect of the Inhibition of Nucleic Acids and Protein Synthesis upon the Development of Melanotic Tumors in <i>Drosophila</i>

Reversible inhibition of mammalian tubulin assembly in vitro and effects in Saccharomyces cerevisiae D61.M by mitomycin C

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