Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata

Celik, Sumeyya Deniz; Ateş, Ömer

doi:10.1002/jcla.22386

Cited by 13 publications

(9 citation statements)

References 25 publications

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“… 47 Despite our negative findings regarding rs187238, rs1946518, and rs549908 SNPs of IL18 gene, the latter two variants were a significant difference in Korean AA cases in comparison to the healthy controls, 47 while the former two variants were associated with AA in the Turkish population. 3 Therefore, IL18 variants are considered major contributors to the etiopathogenesis of AA in some populations.…”

Section: Discussionmentioning

confidence: 99%

“… 1 , 2 It presents with different sizes and patterns of nonscarring hair loss mediated by targeted, organ-specific inflammatory responses of the hair follicles. 3 , 4 There are several subtypes of alopecia, with patchy AA forming 90% of the cases. The remaining 10% include alopecia totalis (AT), alopecia ophiasis (AO), and alopecia universalis (AU), the last one being the severest and the most differentiated form of the disease.…”

Section: Introductionmentioning

confidence: 99%

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Genetic Association between Interleukin Genes and Alopecia Areata in Jordanian Patients

AL-Eitan¹,

Alghamdi²,

Momani³

et al. 2022

Oman Med J

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Objectives Alopecia areata (AA) is a multifactorial autoimmune disease with a strong genetic predisposition. A variety of genes involved in immunity and inflammatory responses, such as cytokines, are suspected to increase the risk of developing AA. In which, different interleukin (IL) genes that associated with several autoimmune diseases and AA in varied populations. The objective of this study was to investigate the possible genetic association of AA with ten variants of single nucleotide polymorphism (SNP) in IL12B,IL13,IL16,IL17A, and IL18 genes among Jordanian patients. Methods In this case-control study, peripheral blood samples of 152 Jordanian AA patients and 150 controls (total of 302 subjects) were collected, genomic DNA extracted and genotyped, based on which their allele and genotype frequencies were assessed. Results In the rs11073001 SNP located in the exon region of the IL16 gene, the A allele was distributed more frequently in AA patients ( p = 0.01). A difference was found between the patients and the controls for the rs17875491 SNP in the promoter region of the IL16 gene ( p = 0.04). The mean age of onset was 27.3±12.6 with male predominance. Most patients (68.4%) were asymptomatic but some reported experiencing associated sensations before the hair loss episodes. The patchy patterns of alopecia were the most common (90.3%). Nail changes were found in 7.3% of the patients. Conclusions The findings support the hypothesis of the involvement of IL16 gene in the etiology of AA. Moreover, it emphasizes the variations in the genetic component of AA, as well as the clinical phenotypes among different ethnic groups.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic Association between Interleukin Genes and Alopecia Areata in Jordanian Patients

AL-Eitan¹,

Alghamdi²,

Momani³

et al. 2022

Oman Med J

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“…AA is a highly prevalent, chronic, and relapsing autoimmune disease that targets hair follicles. IL18 is a significant pro-inflammatory cytokine that is present in high levels in AA patients (Celik and Ates, 2018). Recent data have suggested the possible role of IL17 in AA pathogenesis (Ramot et al ., 2018).…”

Section: Discussionmentioning

confidence: 99%

Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells

Choi

Sung

2019

Biomolecules & Therapeutics

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Udenafil, which is a PDE 5 inhibitor, is used to treat erectile dysfunction. However, it is unclear whether udenafil induces hair growth via the stimulation of adipose-derived stem cells (ASCs). In this study, we investigated whether udenafil stimulates ASCs and whether increased growth factor secretion from ASCs to facilitate hair growth. We found that subcutaneous injection of udenafil-treated ASCs accelerated telogen-to-anagen transition in vivo . We also observed that udenafil induced proliferation, migration and tube formation of ASCs. It also increased the secretion of growth factors from ASCs, such as interleukin-4 (IL-4) and IL12B, and the phosphorylation of ERK1/2 and NFκB. Furthermore, concomitant upregulation of IL-4 and IL12B mRNA levels was attenuated by ERK inhibitor or NFκB knockdown. Application of IL-4 or IL12B enhanced anagen induction in mice and increased hair follicle length in organ culture. The results indicated that udenafil stimulates ASC motility and increases paracrine growth factor, including cytokine signaling. Udenafil-stimulated secretion of cytokine from ASCs may promote hair growth via the ERK and NFκB pathways. Therefore, udenafil can be used as an ASC-preconditioning agent for hair growth.

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“…The genotype distribution of IL-18-rs187238 C > G was statistically meaningfully different in patients with alopecia areata and controls (p = 0.0014). The GG genotype and G allele prevalence were also higher in these sufferers (p = 0.0003 and p = 0.0010, respectively) [43]. In other relevant studies, Migita et al (2008) assessed the relationship between IL-18-rs187238 C > G and -rs1946518 T > G with liver disease progression in patients with chronic HBV.…”

Section: Experimental Standpointmentioning

confidence: 93%

“…Moreover, Celik et al (2018) revealed that the genotype distribution of IL-18-rs1946518 T > G statistically signi cantly differed among alopecia areata sufferers and controls (p = 0.0008). The GG + GT genotype distribution and G allele frequency in this SNP were higher in the case group (p = 0.001 for both) [43]. Although current results differ from the abovementioned studies, they are consistent with those evaluating the association between this SNP and liver-related aberrations.…”

Section: Experimental Standpointmentioning

confidence: 95%

IL-18 and CD14 variants in chronic HBV predisposition: an experimental–bioinformatics study focused on transcription and splicing

Sarhadi

Pahlavani

Razavi

et al. 2022

Preprint

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Background Hepatitis B virus (HBV), a vaccine-avoidable infection, is a health concern worldwide, leading to liver disorders such as acute self-constraint and chronic hepatitis, liver failure, hepatic cirrhosis, and even hepatocellular carcinoma if untreated. ‘Immunogeneticprofiling,’ genetic variations of the pro- and anti-inflammatory cytokines responsible for regulating the immune responses, cause person-to-person differences and impact the clinical manifestation of the disease. The current experimental–bioinformatics research was conducted to examine whether promoteric IL-18–rs187238 C > G and –rs1946518 T > G and intronic CD14–rs2569190 A > G variations are associated with chronic HBV. Methods A total of 400 individuals (200 in each case and control group) participated in the study and were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The data was also assessed bioinformatics-wise for conservation, genomic transcription and splicing, and protein interactions. Results Findings proposed that unlike the IL-18–rs1946518 T > G and CD14–rs2569190 A > G, the IL-18–rs187238 C > G is a protector against chronic HBV (odds ratio [OR] = 0.62, 95% confidence intervals [CI]: 0.46–0.83, and p = 0.002). The TG/CC/AA, TG/CC/AG, TT/CC/AG, and GG/CC/AA combined genotypes significantly increased chronic HBV risk (p < 0.05), while the IL-18 G/T and G/G haplotypes lessened it (p < 0.05). Moreover, in contrast to the IL-18–rs1946518 T > G, IL-18–rs187238 C > G is likely to create novel binding sites for transcription factors, and the CD14–rs2569190 A > G presumably changed the ribonucleic acid splicing pattern. Conclusions The IL-18–rs187238 C > G might protect against chronic HBV and is likely to generate novel binding sites for transcription factors.

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Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata

Abstract: The rs1946518 (-607C>A) and rs187238 (-137G>C) polymorphisms were found associated with alopecia areata disease. The study suggests that IL-18 rs187238 and rs1946518 SNPs may be the cause of the AA susceptibility.

Cited by 13 publications

References 25 publications

Genetic Association between Interleukin Genes and Alopecia Areata in Jordanian Patients

Genetic Association between Interleukin Genes and Alopecia Areata in Jordanian Patients

Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells

IL-18 and CD14 variants in chronic HBV predisposition: an experimental–bioinformatics study focused on transcription and splicing

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