Genetic analysis of CLAWN miniature pigs by blood groups and biochemical polymorphisms.

Oishi, Takao; Nakanishi, Yoshihiko; Tanaka, Kazue

doi:10.5938/youton.28.126

Cited by 4 publications

(3 citation statements)

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“…These results are in line with previous studies that indicated a large genetic difference between Japanese wild boars and Ryukyu wild boars (Watanobe et al 1999). The Clawn miniature pig is an experimental animal breed raised from crossing among Gottingen, Chinese native, Landrace, and Large White pigs (Oishi et al 1991).…”

Section: Resultsmentioning

confidence: 99%

Allele frequency for c.335 A>C polymorphisms in porcine ghrelin/obestatin prepropeptide gene and association analysis with performance traits in various pig breeds

Tanaka¹,

Takizawa²,

Oki³

et al. 2015

CZECH J ANIM SCI

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ABSTRACT:The allelic frequency of c.335A>C polymorphisms in the porcine ghrelin/obestatin prepropeptide (GHRL) gene was surveyed among six pig breeds and two subspecies of wild boars. The c.335C was the most frequent allele in Berkshire, Landrace, Large White, Yorkshire, and Clawn miniature pigs and Ryukyu wild boars (Sus scrofa riukiuanus), whereas c.335A was the most frequent allele in Duroc and Meishan pigs and Japanese wild boars (S. s. leucomystax). The association of c.335A>C with performance traits was analyzed in Duroc, Landrace, Large White, and (Landrace × Large White) × Duroc (LWD) cross-bred pigs. No associations between c.335A>C genotype and average daily weight gain, backfat thickness, or intramuscular fat were detected. However, an association was observed between loin eye muscle area (EMA) and c.335A>C genotype in Duroc gilts. The AA genotype group had larger EMA than the AC genotype group in Duroc gilts; however, this association was not significant in Duroc boars and barrows or the other pig populations investigated. These results demonstrate that GHRL c.335A>C is not a major quantitative trait loci candidate on pig chromosome 13 affecting fat deposition.

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Section: Resultsmentioning

confidence: 99%

Allele frequency for c.335 A>C polymorphisms in porcine ghrelin/obestatin prepropeptide gene and association analysis with performance traits in various pig breeds

Tanaka¹,

Takizawa²,

Oki³

et al. 2015

CZECH J ANIM SCI

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“…Clawn miniature pigs were originally developed in Japan by crossbreeding the F1 offspring of Göttingen Miniature × Ohmini and the F1 offspring of Landrace × Large White, and maintaining a closed colony for over 30 years. The genetic variability of the Clawn strain is the lowest of all the miniature strains including Göttingen, Ohmini and PitmanMoore [16]. Nine healthy 3-to 4-month-old Clawn miniature pigs (8.9 ± 1.2 kg) were purchased from Japan Farm Clawn Institute (Kagoshima, Japan).…”

Section: Animalsmentioning

confidence: 99%

The Effects of Acute Exposure to Deoxynivalenol on Some Inflammatory Parameters in Miniature Pigs

Mikami

Kubo

Murata

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Seven miniature pigs were injected intravenously with deoxynivalenol (DON) at 1 mg/kg body weight; afterward, the number of leukocytes in peripheral blood, the luminol-dependent chemiluminescence of neutrophils, the serum or plasma concentration of cytokines and acute-phase proteins were evaluated to determine the effects of acute exposure to DON on inflammatory responses. White blood cell counts were transiently increased at 3, 6, and 12 hr post-injection (PI) due to the increased number of neutrophils. The luminoldependent chemiluminescence value of neutrophils was significantly elevated at 24 hr PI, indicating the activation of the bactericidal function of neutrophils. Significant increases of interleukin (IL)-8 and tumor necrosis factor- at 3 hr PI and IL-6 at 6 hr PI were detected in the serum. The concentration of haptoglobin and serum amyloid A was significantly increased at 24 hr PI. These results suggest that acute exposure to DON induced a temporary recruitment of neutrophils in the peripheral blood by IL-8 and subsequent activation of the bactericidal function, and a transient increase of proinflammatory cytokines and acute-phase proteins, indicating the immunomodulatory effects of DON in pigs.

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“…Background data regarding body weight and hematological analysis of CLAWN miniature swine are available 9 , but comprehensive histopathological background data have not yet been accumulated. Availability of such a data set for the systemic organs would permit extensive examinations and allow for discussions on safety evaluations.…”

Section: Introductionmentioning

confidence: 99%

Histopathological background data of the systemic organs of CLAWN miniature swine with coronary artery stent implantation

et al. 2017

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The aim of this study was to identify potential changes that could occur during histological evaluations of CLAWN miniature swine, with potential consequences for subsequent experiments. The systemic organs from male and female CLAWN miniature swine (16.3–42.3 months old) that had been used in long-term studies of coronary stent implantation were examined histologically. Commonly observed histopathological findings were testicular/epididymal atrophy, cyst-like follicles in the ovaries, hemosiderin deposition in the spleen, lipofuscin deposition in the proximal tubular epithelia and presence of eosinophilic globules in the Bowman’s space and the lumen of the proximal tubules in the kidneys, and cellular infiltration in several organs, including the eyelids, respiratory organs, and digestive tract. However, none of these changes were serious enough to indicate a significant impact on research. In conclusion, this study identified CLAWN miniature swine as a suitable animal model for various experiments.

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Genetic analysis of CLAWN miniature pigs by blood groups and biochemical polymorphisms.

Cited by 4 publications

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Allele frequency for c.335 A>C polymorphisms in porcine ghrelin/obestatin prepropeptide gene and association analysis with performance traits in various pig breeds

Allele frequency for c.335 A>C polymorphisms in porcine ghrelin/obestatin prepropeptide gene and association analysis with performance traits in various pig breeds

The Effects of Acute Exposure to Deoxynivalenol on Some Inflammatory Parameters in Miniature Pigs

Histopathological background data of the systemic organs of CLAWN miniature swine with coronary artery stent implantation

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Genetic analysis of CLAWN miniature pigs by blood groups and biochemical polymorphisms.

Cited by 4 publications

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Allele frequency for c.335 A&gt;C polymorphisms in porcine ghrelin/obestatin prepropeptide gene and association analysis with performance traits in various pig breeds

Allele frequency for c.335 A&gt;C polymorphisms in porcine ghrelin/obestatin prepropeptide gene and association analysis with performance traits in various pig breeds

The Effects of Acute Exposure to Deoxynivalenol on Some Inflammatory Parameters in Miniature Pigs

Histopathological background data of the systemic organs of CLAWN miniature swine with coronary artery stent implantation

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Allele frequency for c.335 A>C polymorphisms in porcine ghrelin/obestatin prepropeptide gene and association analysis with performance traits in various pig breeds

Allele frequency for c.335 A>C polymorphisms in porcine ghrelin/obestatin prepropeptide gene and association analysis with performance traits in various pig breeds