Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease

Heck, Angela; Fastenrath, Matthias; Coynel, David; Auschra, Bianca; Bickel, Horst; Freytag, Virginie; Gschwind, Leo; Hartmann, Francina; Jessen, Frank; Kaduszkiewicz, Hanna; Maier, Wolfgang; Milnik, Annette; Pentzek, Michael; Riedel‐Heller, Steffi G.; Spalek, Klara; Vogler, Christian; Wagner, Michael; Weyerer, Siegfried; Wolfsgruber, Steffen; Quervain, Dominique J.‐F. de; Papassotiropoulos, Andreas

doi:10.1001/jamapsychiatry.2015.1309

Cited by 24 publications

(23 citation statements)

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“…This test can be complemented by tests of cued recall or recognition, which inform us about item familiarity. The IAPS normalized picture system has been used previously to characterize free recall (Heck et al., ) as well as emotional memory (Dolcos, LaBar, & Cabeza, ; Hofstetter, Achaibou, & Vuilleumier, ). Emotional material is usually better remembered than neutral material (McGaugh, ), and functional interactions during encoding and retrieval have been shown to be affected by emotional valence (Hermans et al., ; Kark & Kensinger, ).…”

Section: Introductionmentioning

confidence: 99%

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Picture free recall performance linked to the brain's structural connectome

et al. 2017

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IntroductionMemory functions are highly variable between healthy humans. The neural correlates of this variability remain largely unknown.MethodsHere, we investigated how differences in free recall performance are associated with DTI‐based properties of the brain's structural connectome and with grey matter volumes in 664 healthy young individuals tested in the same MR scanner.ResultsGlobal structural connectivity, but not overall or regional grey matter volumes, positively correlated with recall performance. Moreover, a set of 22 inter‐regional connections, including some with no previously reported relation to human memory, such as the connection between the temporal pole and the nucleus accumbens, explained 7.8% of phenotypic variance.ConclusionsIn conclusion, this large‐scale study indicates that individual memory performance is associated with the level of structural brain connectivity.

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Section: Introductionmentioning

confidence: 99%

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Picture free recall performance linked to the brain's structural connectome

et al. 2017

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“…Die Arbeiten von Heck et al [10] und Papassotiropoulos et al [11] zeigen in mehreren Kohorten junger und alter Probanden, dass episodische (hippocampusabhängige) Gedächt-nisleistungen mit einer Gruppe von Genvarianten assoziiert sind, die gemeinsam Calciumsignalwege beeinflussen. Interessanterweise sind die gleichen Genvarianten auch mit dem Risiko für die sporadische Alzheimer-Erkrankung assoziiert.…”

Section: Therapiestudien (E2unclassified

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Peters

Heuser

Frölich

et al. 2016

Bundesgesundheitsbl.

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“…Gene set enrichment analysis (GSEA) can be used to improve the detection and the explanatory power of the genetic basis of heritable traits (Wang et al, 2010). Importantly, GSEA is particularly suitable for the study of complex traits, which are characterized by small genetic effects of multiple genetic variants that contribute to the trait in question (Lohmueller et al, 2003), as demonstrated by previous studies (Heck et al, 2014;Heck et al, 2015;Lips et al, 2012;Nurnberger et al, 2014). Specifically, it tests whether multiple genes with modest associations with a given complex trait are enriched in specific biological process.…”

Section: Introductionmentioning

confidence: 99%

The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals

Petrovska

Coynel

Fastenrath

et al. 2017

Journal of Psychiatric Research

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Depressive symptoms exist on a continuum, the far end of which is found in depressive disorders. Utilizing the continuous spectrum of depressive symptoms may therefore contribute to the understanding of the biological underpinnings of depression. Gene set enrichment analysis (GSEA) is an important tool for the identification of gene groups linked to complex traits, and was applied in the present study on genome-wide association study (GWAS) data of depression scores and their brain-level structural correlates in healthy young individuals. On symptom level (i.e. depression scores), robust enrichment was identified for two gene sets: NCAM1 Interactions and Collagen Formation. Depression scores were also associated with decreased fractional anisotropy (FA) - a brain white matter property - within the forceps minor and the left superior temporal longitudinal fasciculus. Within each of these tracts, mean FA value of depression score-associated voxels was used as a phenotype in a subsequent GSEA. The NCAM1 Interactions gene set was significantly enriched in these tracts. By linking the NCAM1 Interactions gene set to depression scores and their structural brain correlates in healthy participants, the current study contributes to the understanding of the molecular underpinnings of depressive symptomatology.

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Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease

Cited by 24 publications

References 59 publications

Picture free recall performance linked to the brain's structural connectome

Picture free recall performance linked to the brain's structural connectome

Das Kompetenznetz Demenzen

The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals

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