Genetic analysis of 17 Y-chromosomal STRs haplotypes of Chinese Tibetan ethnic group residing in Qinghai province of China

Haplotype analysis of the polymorphic 40 Y-STR markers in Chinese populations

“…Thirty-eight Y-STR loci, except DYS391 (0.441658) and DYS437 (0.496977), revealed GD values greater than 0.5, exhibiting a high level of genetic polymorphisms in the total populations. The DYS391 and DYS437 loci were also observed to be poorly diverse markers in previous population studies [2][3][4][5][6], which were present in the most commonly used Y-STR typing kits, such as Yfiler, PPY23, Goldeneye 20Y and AGCU Y24 (Table 1) Copy number variants were most abundant at markers DYS527a/b (n = 15), followed by DYS19 (n = 4) and DYS385a/b (n = 2). Duplications at the Y-STR locus were reported by a number of previous studies [20,23].…”

“…China is composed of multi-ethnic groups, and it is important to study the genetic information of all of the groups to obtain a good understanding of their genetic backgrounds and inter-population relationships [1]. However, the majority of the published data are focused on the Yfiler 17 loci or fewer Y-STR loci levels [2][3][4][5][6]. Moreover, the selection of Y-STR loci for most of the existing commercial kits is primarily based on the European, African and South Asian population data [7], of which some markers, such as DYS438 and DYS391, were revealed as not highly diverse in Chinese populations [5,6].…”

Y-STR diversity in the Himalayas

“…Although several studies based on Y-STR data from Tibet have been previously published [23][24][25][26], the present study is the first of its kind to perform comprehensive phylogenetic analyses involving a considerable sample size. The knowledge of the phylogenetic relationships among populations is essential in order to assess whether or not populations should be considered as a separate entity as databases for forensic analysis and paternity testing.…”

Enriching the knowledge on East Asia populations: Characterization of male lineages from Macau and Shanghai

“…For the population analyses, the SAMOVA v2.0 software [6] was used, as well as SPSS v21.0 for the Multidimensional Scale (MDS) representation of the genetic distances (R ST ). Comparisons were carried on with data from several East Asian populations/ethnicities: Tibetans from Qinghai [7] and Lhasa [8]; Salars from Xunhua [9]; Huis from Ningxia [10]; Manchus from Xinbin [11]; Tujias from Youyang [12]; Kazakhs and Uighurs from Xinjiang [13]; and Hans from Shandong [14], Shanxi [15], Henan [16], Luzhou [17], Mudanjiang [18] and Taiwan [19].…”