Genetic Analysis and Natural History of Parkinson’s Disease Due to the LRRK2 G2019S Variant
Matthew J. Kmiecik,
Steven Micheletti,
Daniella Coker
et al.
Abstract:The LRRK2 G2019S variant is the most common cause of monogenic Parkinson's Disease (PD); however, questions remain regarding the penetrance, clinical phenotype, and natural history of carriers. We performed a 3.5 year prospective longitudinal online study in a large number of 1,286 genotyped LRRK2 G2019S carriers and 109,154 controls, with and without Parkinson's disease (PD) recruited from the 23andMe Research Cohort. We collected self-reported motor and non-motor symptoms every six months, as well as demogra… Show more
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