“…We have studied an Argentinean patient that had clinical and biochemical criteria suggestive of CH associated with TG gene deficiency: lower serum TG and high levels of serum TSH with simultaneous low levels of circulating thyroid hormones [Targovnik et al, 2010a[Targovnik et al, , 2011 -Hassan et al, 2013;Brust et al, 2011;Caputo et al, 2007aCaputo et al, , 2007bCitterio et al, 2011Citterio et al, , 2013aGutnisky et al, 2004;Machiavelli et al, 2010;Nicholas et al, 2016;Pardo et al, 2009;Peteiro-Gonzalez et al, 2010;Rivolta et al, 2005;Siffo et al, 2018;Santos-Silva et al, 2019;van de Graaf et al, 1999;Zou et al, 2018]. This mutation was available in heterozygous state from gnomAD database in Ashkenazi Jewish, Latino, Europeans (non Finnish), European (Finnish), African and South Asian populations with an estimated total Minor Allele Frequency (MAF) of 0.0003535 % (100/282,884) for the allele thymine 886 .…”