Genetic amniocentesis in twin pregnancies: results of a multicenter study of 529 cases

Pruggmayer, M.; Jahoda, M. G. J.; Pol, J.G. van der; Baumann, Pia; Holzgreve, Wolfgang; Karkut, G; Lettau, R.; Eiben, B.; Osmers, R.; Gola, H. W.; Duda, Volker; Polák, Petr; Körner, H.; Schulte-Valentin, M.; Schutte, H

doi:10.1046/j.1469-0705.1992.02010006.x

Cited by 45 publications

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“…Coleman et al [24] reported a proportion of fetal losses of 5.0% before the 28th week of gestation. Multicenter studies including a high number of cases put fetal loss before the 28th week of pregnancy at 3.8% [8]. In the sample of pregnant women examined by us, the spontaneous loss rate in multiple pregnancies was found to be 5.89% between the 18th and the 28th gestational week.…”

Section: Discussionmentioning

confidence: 76%

“…In multiple pregnancies, the incidence of chromosomal disorders grows parallel to the frequency of [2,8,9,16]. It is also well known that in multiple pregnancies the risk of fetal anatomical disorders and maternal age-specific chromosomal disorders is higher [4,16].…”

Section: Discussionmentioning

confidence: 99%

“…The ratio of monozygotic and dizygotic twins has been found almost constant at 1/3 and 2/3, respectively [5,6]. However, the incidence of dizygotic twins appears to be on the rise among women over 35 years of age [7][8][9]. The second reason for the increase lies in the growing usage of assisted reproductive techniques.…”

Section: Introductionmentioning

confidence: 99%

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Genetic Amniocentesis in Multiple Pregnancy

et al. 2004

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Objectives: Second-trimester genetic amniocentesis is the most frequently used invasive prenatal diagnostic technique. Several reports have been published about the effect of genetic amniocentesis on fetal loss in multiple pregnancies over the past two decades. Here we analyze our experience with genetic amniocentesis in multiple pregnancies over the past 10 years. Methods: Details of 184 multiple pregnancies were processed in all cases in whom genetic amniocentesis was performed in women who presented at our department since 1990. The outcomes of 175 cases (95.1%) out of 184 genetic amniocenteses were available to us. As a control group, we followed up the outcome of 300 twin pregnancies in which no genetic amniocenteses were performed. Results: We found that the proportion of spontaneous losses in multiple pregnancies between the 18th and the 24th gestational weeks was 2.39%, whereas if genetic amniocentesis was performed the loss rate before the 24th week was 3.87%. The perinatal mortality rate was 10.03/1,000 in the group who underwent amniocentesis, while it was 10.52/1,000 in the group without amniocentesis. Conclusions: Our results suggest that the genetic amniocentesis performed in multiple pregnancies slightly increased (1.48%) the fetal loss rate until the 24th week. Beyond 5 weeks after the procedure, no consequent fetal loss should be expected. In our study the intervention did not have any undesired effect on perinatal mortality rates.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

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Genetic Amniocentesis in Multiple Pregnancy

et al. 2004

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“…We use fetal loss rate data from the multicentre study of Pruggmeyer et al (1992), because this study provides the most recent and complete results after prenatal diagnosis in twin pregnancies. In the present study, it is assumed that the fetal loss rate and the risk of prenatal diagnosis are the same for all maternal ages.…”

Section: Methodsmentioning

confidence: 99%

A quantitative estimation of the effect of prenatal diagnosis in dizygotic twin pregnancies in women of advanced maternal age

et al. 1994

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Genetic counselling in a dizygotic twin pregnancy is complicated by the large number of possible pregnancy outcomes and by the conceivable differences in the parental valuation of these outcomes. We present the probability distributions of the pregnancy outcomes in dizygotic twin pregnancies for women from 35 to 45 years old without prenatal diagnosis and with transabdominal chorionic villus sampling (TA-CVS) or amniocentesis (AC), using data from the literature. TA-CVS always gives a higher probability of a favourable pregnancy outcome (the birth of one or two infants with a normal karyotype) than AC. For a 35-year-old woman, a 0.7 per cent risk of an unfavourable pregnancy outcome without prenatal diagnosis has to be weighed against the 2.1 per cent excess risk of loss of the entire pregnancy after TA-CVS. For a 45-year-old woman, a 10.2 per cent risk of an unfavourable pregnancy outcome without TA-CVS has to be balanced against a 4.4 per cent excess risk of pregnancy loss after TA-CVS. This study provides a quantitative tool for the support of individual parents with respect to the decision to undergo prenatal diagnosis in a dizygotic twin pregnancy.

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“…Fig. 1 shows the pregnancy loss rates before 20 and 28 weeks' gestation in various studies [12][13][14][15][16][17][18][19][20]. Pregnancy loss rates in these studies ranged from 0 to 6% up to 20 weeks and from 0 to 8% up to 28 weeks.…”

Section: Loss Rates After Amniocentesis In Multiple Gestationsmentioning

confidence: 98%