Genetic Alterations in Urinary Bladder Carcinosarcoma: Evidence of a Common Clonal Origin

Halachmi, Sarel; DeMarzo, Angelo M.; Chow, Nan Haw; Halachmi, Naomi; Smith, Ann E.; Linn, Jürgen F.; Nativ, Ofer; Epstein, Jonathan I.; Schoenberg, Mark; Sidransky, David

doi:10.1159/000052369

Cited by 59 publications

(52 citation statements)

References 18 publications

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“…Increases in SNAIL2 can result in loss of adhesiveness associated with reduction in E-cadherin leading to increased invasiveness (32). Reduction of E-cadherin has been observed in analysis of soft tissue sarcomas (33), but there is limited evidence regarding E-cadherin expression in mixed mullerian tumor (34). Although our group has previously noted cadherin mutation in association with endometrial carcinomas (35), there have been no prior reports by our group or others regarding E-cadherin expression or SNAIL2 in uterine sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Microarray Analysis of Endometrial Carcinomas and Mixed Mullerian Tumors Reveals Distinct Gene Expression Profiles Associated with Different Histologic Types of Uterine Cancer

Maxwell

Chandramouli

Dainty³

et al. 2005

Clinical Cancer Research

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Previous studies using cDNA microarray have indicated that distinct gene expression profiles characterize endometrioid and papillary serous carcinomas of the endometrium. Molecular studies have observed that mixed mullerian tumors, characterized by both carcinomatous and sarcomatous components, share features that are characteristic of endometrial carcinomas. The objective of this analysis was to more precisely define gene expression patterns that distinguish endometrioid and papillary serous histologies of endometrial carcinoma and mixed mullerian tumors of the uterus. One hundred nineteen pathologically confirmed uterine cancer samples were studied (66 endometrioid, 24 papillary serous, and 29 mixed mullerian tumors). Gene expressions were analyzed using the Affymetrix Human Genome Arrays U133A and U133B Genechip set. Unsupervised analysis revealed distinct global gene expression patterns of endometrioid, papillary serous, mixed mullerian tumors, and normal tissues as grossly separated clusters. Two-sample t tests comparing endometrioid and papillary serous, endometrioid and mixed mullerian tumor, and papillary serous and mixed mullerian tumor pairs identified 1,055, 5,212, and 1,208 differentially expressed genes at P < 0.001, respectively. These data revealed that distinct patterns of gene expression characterize various histologic types of uterine cancer. Gene expression profiles for select genes were confirmed using quantitative PCR. An understanding of the molecular heterogeneity of various histologic types of endometrial cancer has the potential to lead to better individualization of treatment in the future.

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Section: Discussionmentioning

confidence: 99%

Microarray Analysis of Endometrial Carcinomas and Mixed Mullerian Tumors Reveals Distinct Gene Expression Profiles Associated with Different Histologic Types of Uterine Cancer

Maxwell

Chandramouli

Dainty³

et al. 2005

Clinical Cancer Research

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“…Carcinosarcomas or sarcomatoid carcinomas are extremely rare malignancies, which have a biphasic character involving epithelial and mesenchymal components (2). Loss of heterozygosity in stem cells is considered as the main factor in the underlying development of sarcomatoid carcinomas (2,3). In addition, cyclophosphamide chemotherapy, smoking, and radiotherapy are considered to play a role in the etiology (4,5).…”

Section: Introductionmentioning

confidence: 99%

Bladder carcinosarcoma: A case report with review of the literature

Basibuyuk

Topaktaş

Elbir

2017

Arch Ital Urol Androl

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Carcinosarcoma of the urinary bladder is a rare neoplasm that is histologically composed of malignant epithelial and mesenchymal components. The etiology of sarcomatoid tumors is unclear, but smoking and history of previous radiotherapy or chemotherapy may lead to bladder disorders and to the formation of sarcomatoid carcinoma. These neoplasms behave as highly aggressive tumors and optimal treatment is uncertain. Herein, we report a case of sarcomatoid carcinoma of urinary bladder presenting as a giant intravesical mass in a 61-year-old man complaining of macroscopic hematuria.KEY WORDS: Bladder carcinosarcoma; Urothelial carcinoma; Prognosis. had a catheter without any other remarkable finding. Laboratory test results were normal. Whole abdominal ultrasonography (USG) showed a 9 x 8 cm mass which filled the bladder. Abdominopelvic computerized tomography (CT) showed a 9 x 7 cm mass lesion, originating from the right lateral wall of the bladder and occupying the entire bladder (Figure 1). A written informed consent was obtained from the patient and cystoscopic examination was performed under general anesthesia. The mass, which originated from the bladder neck and filled the bladder, was incompletely resected. Pathological examination showed a biphasic pattern, and the result was reported as a sarcomatoid carcinoma. The epithelial component included an adenocarcinoma and squamous-cell carcinoma, whereas the sarcomatous component included a spindle-cell and chondrosarcoma. As the all resection specimen consisted of tumor tissues, we were unable to evaluate the depth of invasion. Computed tomography showed no sign of lymph node or organ metastasis. Four weeks after transurethral resection (TUR-BT), radical cystoprostatectomy, lymph node dissection, and ileal conduit surgery were performed. Cystoprostatectomy specimen had a 10 x 8.5 cm tumor in-diameter (Figure 2). After histological examination, tumor was reported as a high-grade sarcomatoid carcinoma, pT2a, pN0, pMx. The histological pattern consisted of 70% sarcomatous component (spindle-cell and chondrosarcoma), and 30% epithelial component (adenocarcinoma and squamous-cell carcinoma). All surgical margin samples and lymph nodes were reported as normal. Four days after the surgery, the patient died due to myocardial infarction.

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“…[17][18][19][20] For example, studies examining loss of heterozygosity in patients with CS of the bladder found identical patterns between the epithelial and sarcomatoid components of the tumors, [18][19][20] although identical patterns were more frequent in genetic alterations related to early events in bladder carcinogenesis rather than those associated with later events. 18,20 In addition, identical TP53 mutations and concordant p53 expression patterns were detected in both the epithelial and sarcomatoid tumor components in 5 of 17 patients with CS of the urinary bladder. 17 In our case, however, TP53 sequencing of exons 5, 7 and 8 in the urothelial carcinoma and in the angiosarcoma tissue failed to detect TP53 mutations, and immunostaining for p53 was positive in a very low percentage of cells in both components.…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the upper urinary tract with an aggressive angiosarcoma component

Cuadra‐Urteaga

Font

Tapia

et al. 2016

Cancer Biology & Therapy

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Genetic Alterations in Urinary Bladder Carcinosarcoma: Evidence of a Common Clonal Origin

Cited by 59 publications

References 18 publications

Microarray Analysis of Endometrial Carcinomas and Mixed Mullerian Tumors Reveals Distinct Gene Expression Profiles Associated with Different Histologic Types of Uterine Cancer

Microarray Analysis of Endometrial Carcinomas and Mixed Mullerian Tumors Reveals Distinct Gene Expression Profiles Associated with Different Histologic Types of Uterine Cancer

Bladder carcinosarcoma: A case report with review of the literature

Carcinosarcoma of the upper urinary tract with an aggressive angiosarcoma component

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