Parkinson's disease (PD), the second most common neurodegenerative disease, has a great impairment on patients' motor and nonmotor skills. 1 After an initial "honeymoon" period, during which medication can be effective, beneficial effects of medication are hampered by motor complications and progressive motor impairment. 2 Fortunately, subthalamic nucleus deep brain stimulation (STN-DBS), a powerful neuromodulation therapy, has been reported to be effective in treating motor symptoms, such as bradykinesia, rigidity, and tremor, in advanced 3,4 as well as early-stage PD patients. 2