“…Therefore, searching for novel biomarkers that acts as key molecules andtargetsinthedevelopmentofgastrointestinaltumorscanprovidesuggestionsfordetermining treatmentplansandpredictingprognosis,furtherexplorenewdrugtargets,andprovidetheoreticaland experimentalbasesforthedevelopmentoftargetedtherapies (Jageretal.,2000;García-Barrios,2021). The NCAPG protein is one of the subunits of the concentrate I complex of mitogen-associated chromosomalproteinconcentrateandisinvolvedintheconcentrationandstabilizationofmitosisand meiosis (Lam,Peterson,Yeung,&Lavoie,2006).StudiesshowedthattheNCAPGproteinaffectsa varietyofhumantumors (Panetal.,2019).Inaddition,theknockdownofNCAPGexpressioncan promotecellapoptosisandreducecellmigrationabilityandissignificantlycorrelatedwithprognosis (Arai et al, 2018;Mavrinac, M.,2022), thus becoming a tumor marker for liver cancer, thyroid cancer,andmanyothertumordiseases (Panetal.,2019;Zhangetal.,2018;Sanchez-Carmona,2021). However,theexpressionandimportanceoftheNCAPGproteiningastrointestinaltumorshavenot beenfullyrecognized.…”