Genetic activity of vinylidene chloride in yeast

Bronzetti, G.; Bauer, C.; Corsi, C.; Leporini, C.; Nieri, R.; Carratore, R. Del

doi:10.1016/0165-1218(81)90123-3

Cited by 40 publications

(11 citation statements)

References 11 publications

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“…Dagegen wurde in neueren Untersuchungen keine mutagene Wirkung von gereinigtem TRI in Anwesenheit von Leber-S9-Mix gefunden (McGregor et al 1989;NTP 1988;Shimada et al 1985). Untersuchungen zur Induktion von Genmutationen in Hefen (S. cerevisiae) und Pilzen (A. nidulans) lieferten ähnliche Ergebnisse: nicht signifikante bis geringe Mutagenität bei Zusatz von Leber-S9-Mix (Bronzetti et al 1978;Callen et al 1980;Crebelli et al 1985;Crebelli und Carere 1989;Shahin und von Borstel 1977). In A. nidulans induzierte TRI eindeutig Aneuploidie (Crebelli et al 1985), während es in CHO-Zellen in An-und Abwesenheit eines metabolischen Aktivierungssystems keine Chromosomenaberrationen verursachte (NTP 1988).…”

Section: In Vitrounclassified

“…Die Aussagekraft der Studie mit der wiederholten Applikation ist jedoch durch die ungewöhnlich hohe Mikrokernfrequenz in den Kontrolltiere stark limiticrt. Im Host-mediated-assay war kommerziell erhältliches TRI nicht spezifizierter Reinheit positiv (Bronzetti et al 1978), gereinigtes, epoxidfreies TRI dagegen negativ (Rossi et al 1983). TRI (131,4 mg/kg KG, i.p.)…”

Section: In Vivounclassified

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Trichlorethen [MAK Value Documentation in German language, 1996]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 22. Lieferung, Ausgabe 1996 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Toxikokinetik und Metabolismus Vergleichende Toxikokinetik bei Maus, Ratte und Mensch Oxidativer Metabolismus Reduktiver Metabolismus Erfahrungen beim Menschen Akute Toxizität Chronische Toxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Leber, Niere Zentralnervensystem Immunsystem Blutbild Wirkung auf Haut und Schleimhäute Reproduktionstoxizität Genotoxizität In vitro In‐vitro‐Genotoxizität der Metaboliten In vivo Bindung an Protein und DNA Kanzerogenität Bewertung

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Section: In Vitrounclassified

Section: In Vivounclassified

Trichlorethen [MAK Value Documentation in German language, 1996]

2012

The MAK‐Collection for Occupational Health and Safety

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“…Cells from the stationary phase of growth were treated with the fruit extract. Afterwards, cell suspensions were processed following the methodology described by Bronzetti et al (1981). For assays with metabolic activation, rat-liver S9 fraction was used.…”

Section: Saccharomyces Cerevisiae Assaymentioning

confidence: 99%

Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts

Sánchez-Lamar¹,

Fonseca²,

Fuentes³

et al. 2008

Journal of Ethnopharmacology

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“…Cells were washed and plated on selective media to ascertain trp convertants and ilv revertants 18 . The same experimental procedure was performed with stationary phase cells, grown in 2% glucose.…”

Section: Yeast Strainmentioning

confidence: 99%

Genetic and biochemical studies on a commercial preparation of atrazine

Morichetti¹,

Croce²,

Rosellini³

et al. 1992

Toxicological & Environmental Chemistry

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A commercial preparation of atrazine was tested in diploid strain (D 7 ) of yeast Saccharomyces cerevisiae in suspension test using cells from logarithmic growth phase (with a high level of cytochrome P-450) and stationary growth phase. This compound induced a marked increase of both gene conversion and point mutation in logarithmic phase cells, while in stationary phase cells only an increase of gene conversion was observed. Results obtained employing TA98 and TA100 strains of Salmonella typhimurium (Ames test) confirm that atrazine has no mutagenic effect.The in vivo effects on cytochrome P-450 content (Cyt.P-450), 7-ethoxycoumarin-O-deethylase (ECD), aminopyrine-N-demethylase (APD), p-nitroanisole-O-demethylase (p-NAD) activities were examined in hepatic microsomes from Naphenobarbital and β-naphthoflavone induced pigs 24 h after acute intoxication with atrazine. Our results indicated a marked decrease of cytochrome P-450 level and of microsomal protein content, suggesting a hepatotoxic effect of atrazine in vivo.

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Genetic activity of vinylidene chloride in yeast

Cited by 40 publications

References 11 publications

Trichlorethen [MAK Value Documentation in German language, 1996]

Trichlorethen [MAK Value Documentation in German language, 1996]

Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts

Genetic and biochemical studies on a commercial preparation of atrazine

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