Genesis of the Adrenocortical Secretion

“…The main glucocorticoid hormone that is released in response to stresses, including pain, is cortisol (Hecter and Pincus, 1954;Weary et al, 2006). The corticosteroid level can be measured in plasma or saliva and is a widespread means for the physiological assessment of the activity of the hypothalamus-pituitary-adrenal axis, which is activated in painful conditions .…”

Section: Physiological Responses To Painmentioning

confidence: 99%

Pathophysiologic mechanisms of pain in animals A review

Okafor¹,

Remi-Adewunmi²,

Fadason³

et al. 2014

J. Vet. Med. Anim. Health

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The sense of pain is of practical significance in human and veterinary medicine. Its management and prevention constitute integral and fundamental parts of quality and compassionate care of patients. In order to recognise, assess, prevent and treat pain, an understanding of its pathway and the pathophysiologic mechanisms is necessary. This review discusses definitions of pain, its classification, description, pathophysiologic mechanisms, neuro-transmission and evaluation of pain as well as physiological responses to pain, with special reference to domestic animals. It is concluded that adequate understanding of pathophysiologic mechanisms of pain and the physiologic responses of animals to pain may aid its efficient management.

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“…It was thought that the size of the adrenal gland was dependent only on ACTH; however, Lostroh and co-workers showed that the adrenal hypertrophy following ACTH administration in the mouse could be enhanced by the presence of growth hormone, although the latter hormone alone had no effect on adrenal weight (44 (63,64), because the gland has already been maximally stimulated by the stress of the operative procedures (54).…”

Section: Effects Of Acth Onmentioning

confidence: 99%