Genesis of Preeclampsia: An Epidemiological Approach

Salvador-Moysén, Jaime; Martínez-López, Yolanda; Ramírez-Aranda, José Manuel; Aguilar-Durán, Marisela; Terrones-González, Alberto

doi:10.5402/2012/916914

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…Such SNS overactivity can be triggered by uterine blood flow restriction, as hypoxia is a strong SNS activator (Rook et al , 2014). However, there are also epidemiological data indicating associations of psychosocial stress in pregnancy with increased risk of preeclampsia, suggesting that the elevated NPY levels observed specifically in MTPE may reflect maternal chronic stress (Klonoff-Cohen et al , 1996; Kurki et al , 2000; Paarlberg et al , 1995; Salvador-Moysen et al , 2012; Sandman et al , 1997; Wadhwa et al , 1996). …”

Section: Discussionmentioning

confidence: 99%

Elevated levels of neuropeptide Y in preeclampsia: A pilot study implicating a role for stress in pathogenesis of the disease

et al. 2016

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Objective To determine if preeclampsia (PE) is associated with dysregulation of the neuropeptide Y (NPY) system. Methods The study enrolled 114 subjects either with normal pregnancy (NP) or with PE. Systolic blood pressure (SBP) was collected from patients using a standard sphygmomanometer. The PE patients were divided into two groups based on the gestational age (GA) at delivery – placental PE (PLPE, GA <34 weeks) or maternal PE (MTPE, GA ≥ 34 weeks). NPY was measured in platelet rich plasma (PRP), platelet poor plasma (PPP) and in the serum of NP and PE patients utilizing radioimmunoassay. Serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) were measured in NP and PE subjects by ELISA. Results SBP was higher in PE compared to NP. Circulating NPY in serum and PRP, as well as NPY content per 100,000 platelets, but not its concentrations in PPP, were elevated in PE, as compared to NP. The highest NPY concentrations were observed in sera and PRP of patients with MTPE. PE patients had also elevated levels of sFlt-1, as compared to NP, although no difference between PLPE and MTPL groups were observed. There was no increase in P1GF in PE patients. Conclusion Systemic NPY is elevated in PE patients, as compared to NP. This increase is observed in blood fractions containing platelets, suggesting accumulation of the peptide in these cells. NPY concentrations are particularly high in patients with MTPE, underlying differences in etiology between PLPE and MTPE. Our study implicates NPY as a potential target in antihypertensive therapies for PE patients.

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Section: Discussionmentioning

confidence: 99%

Elevated levels of neuropeptide Y in preeclampsia: A pilot study implicating a role for stress in pathogenesis of the disease

et al. 2016

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“…The association between PE and epigenetic alterations of the placenta (6)(7)(8) has been recently reported. The maternal epigenome has a unique history that can be useful to study in order to understand its susceptibility to develop PE, as well as to detect it in its early stages (10).…”

Section: Introductionmentioning

confidence: 99%

“…Various studies have documented an association between adverse cultural and psychosocial situations with a high frequency of gestational morbimortality (6,7). Research-based approaches establish a clear association between a context characterized by high social stressors and low psychosocial support with the expression of PE.…”

Section: Introductionmentioning

confidence: 99%

Differential Methylation in Promoter Regions of the Genes NR3C1 and HSP90AA1, Involved in the Regulation, and Bioavailability of Cortisol in Leukocytes of Women With Preeclampsia

et al. 2020

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Introduction: Hypertensive disorders are of interest in obstetrics and gynecology because they are the second place among causes of maternal mortality and a source of complications in the short, mid, and long term. Even if the pathophysiological process behind preeclampsia (PE) is still unknown, stress factors have been revealed to play an important role in the genesis of this pathologic process. Methods: A case-control study was designed with the purpose of determining if there is a differential methylation in NR3C1, HSD11B2, CYP11A1, CRHBP, TEAD3, and HSP90AA1 genes, related to signaling of the hypothalamic-pituitary-adrenal axis, and its regulation on early-onset PE (EOPE). Results: A total of 20 cases and 20 controls were studied by DNA methylation analysis, demonstrating differences among groups in the percentage of methylation of the NR3C1 gene. After a contingency analysis, an odds ratio (OR) for PE of 12.25 was identified for NR3C1 and 9.9 for HSP90AA1 genes. NR3C1, TEAD3, and HSP90AA1 genes showed a positive correlation with the systolic and diastolic blood pressure levels with a p ≤ 0.05. Conclusion: This study found a differential methylation in the glucocorticoid receptor (GR) NR3C1 and its co-chaperone HSP90AA1 in women with PE, with a possible regulatory role in the response to stress in pregnancy and is a likely physiopathological mechanism in PE.

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Leisure Time Physical Activity and the Risk of Pre-eclampsia: A Systematic Review

Wolf

Owe

Juhl

et al. 2013

Matern Child Health J

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Today, pre-eclampsia (PE) is one of the leading causes of maternal and perinatal morbidity and mortality. It has been proposed that leisure time physical activity (LTPA) is associated with a decreased risk of PE. The objective of this study was to perform a systematic literature review examining the association between LTPA before and/or during pregnancy and the risk of PE. A systematic search of the EMBASE and PUBMED databases from inception to November 17, 2011 was conducted by two independent reviewers. Only studies describing the association between the intensity or amount of LTPA before and/or during pregnancy and the risk of PE were included. A narrative synthesis of the results was undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A quality assessment was performed using the Newcastle Ottawa Scale. Eleven studies were included. None of the studies found light- or moderate-intensity LTPA to be associated with PE. Three studies reported that vigorous-intensity LTPA before and/or during pregnancy may reduce the risk of PE. One study reported a reduced risk among women who participated in LTPA at least 25 times per month or more than 4 h per week. However, one study found an elevated risk of severe PE with high amounts of LTPA, defined as 4.5 h per week or more. Results are mixed, but high intensity LTPA before and/or during pregnancy or more than 4 h per week of LTPA may reduce the risk of PE. However, an urgent need remains for high-quality studies including different ethnicities to further explore this relationship.

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Genesis of Preeclampsia: An Epidemiological Approach

Cited by 5 publications

References 38 publications

Elevated levels of neuropeptide Y in preeclampsia: A pilot study implicating a role for stress in pathogenesis of the disease

Elevated levels of neuropeptide Y in preeclampsia: A pilot study implicating a role for stress in pathogenesis of the disease

Differential Methylation in Promoter Regions of the Genes NR3C1 and HSP90AA1, Involved in the Regulation, and Bioavailability of Cortisol in Leukocytes of Women With Preeclampsia

Leisure Time Physical Activity and the Risk of Pre-eclampsia: A Systematic Review

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