Genes required for the formation of virulence-provoking bacterial sphingolipids
Roberto Jhonatan Olea-Ozuna,
Sebastian Poggio,
Ed Bergström
et al.
Abstract:Sphingolipids are ubiquitous in membranes of eukaryotes and are associated with important cellular functions. Although sphingolipids occur scarcely in bacteria, for some of them they are essential and, in other bacteria, they contribute to fitness and stability of the outer membrane, such as in the well-studied α-proteobacteriumCaulobacter crescentus. We previously defined five structural genes for ceramide synthesis inC. crescentus. However, other mutants affected in genes of this same genomic region show cof… Show more
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