Genes related to the metabolism of nutrients in the Kola Sami population

Abstract

Objectives. The environmental and lifestyle conditions of the Kola Sami could have influenced the population-specific frequencies of the AGXT Pro11Leu allele, and certain alleles of APOE and LCT genes, involved respectively, in the metabolism of animal proteins, lipids and milk sugar. Study Design. DNA samples were collected from the Sami population of Lovozero settlement (Murmansk Region) in 00. Methods. The analysis of the traditional diet of the Kola Sami was made using the data of ethnographic studies conducted in the nineteenth and beginning of the twentieth centuries. Frequencies of the AGXT Pro11Leu, APOE*e4 alleles and LCT gene CC-1910 genotype were defined by molecular-genetic analysis. Results. The specificity of the Kola Sami gene pool is in the lower frequency of АРОЕ*e4 allele compared with the Sami of Finland (0.0 and 0.10, respectively) and when compared with other groups (except the Skolt) in the higher frequency of hypolactasia conditioned by the CC-1910 genotype of the LCT gene (0.8). Conclusions. The high prevalence of the AGXT allele T bearers among Kola Sami (0.7) does not contradict the hypothesis of the adaptive role this allele plays in populations with a traditionally high intake of meat.

Prevalence of self-reported stomach symptoms after consuming milk among indigenous Sami and non-Sami in Northern- and Mid-Norway – the SAMINOR study

“…In northernmost Finland, the prevalence varies from 25 to 60% among the Finnish Sami population ( 10 ). Similar studies have been conducted among Sami people in Kola, Russia, which also show a high prevalence of lactose intolerance, as in other indigenous circumpolar populations of Eurasia ( 12 , 13 ). Remarkably, in subjects of mixed ethnicity, a lower prevalence is detected in the native ethnic groups ( 4 ).…”

Childhood violence and adult chronic pain among indigenous Sami and non-Sami populations in Norway: a SAMINOR 2 questionnaire study

“…More stomach symptoms among the Sami were found after consuming milk, suggesting a higher prevalence of milk intolerance among the Sami than the majority population (33). Other studies among Sami in Finland and Russia confirm the higher prevalence of lactose intolerance compared to the majority populations (34,35). Moreover, a study based on SAMINOR data reported a higher prevalence of angina pectoris (heart cramp) among the Sami compared to the non-Sami (36).…”

Adherence to a traditional lifestyle affects food and nutrient intake among modern swedish sami

“…As there are apparent changes in disease risk among Sami, understanding what role diet plays in this change in risk is important for any public healthbased attempts to prevent an increase in lifestyle-related diseases that have afflicted other Indigenous populations (15)(16)(17)(18). Diet may play an important role in the risk of disease among Sami, as they have adapted to a diet high in protein and fat, and low in carbohydrate as part of their traditional lifestyle of hunting and reindeer herding (2,(19)(20)(21). Diet and the risk of disease among Sami has been recently reviewed (22).…”