Genes Expressed in the Adult Brain of<i>Drosophila</i>and Effects of Their Mutations on Behavior: A Survey of Transmitter- and Second Messenger-Related Genes

Buchner, Erich

doi:10.3109/01677069109167432

Cited by 68 publications

(39 citation statements)

References 270 publications

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“…The Fast and Slow replicate lines were significantly diverged from Generation 25. We analyzed the mating speed data from generations [25][26][27][28][29] …”

Section: Resultsmentioning

confidence: 99%

“…These include mutations in genes required for normal morphology [white (13,14), yellow (14), and curved (15)], as well as genes involved in learning and memory [Calcium calmodulin kinase II (16), dunce (17,18), rutabaga (19,20), turnip (19,21), and amnesiac (20,22,23)], circadian rhythm [period (18,(24)(25)(26)] and dopamine and serotonin synthesis [Dopa decarboxylase (27), pale (28,29), tan (30,31), and ebony (32)(33)(34)], sex determination [doublesex (35)(36)(37), transformer (38)(39)(40)(41)(42)(43), fruitless (44)(45)(46)(47), and sex lethal (48)], pheromone production [desaturase 2 (49)], and accessory gland-specific peptides (6-8, 50-52). a subset of loci identified by mutational analysis, or will the analysis of natural variants reveal novel loci?…”

Section: Drosophila Mating Behaviormentioning

confidence: 99%

See 1 more Smart Citation

Genetics and genomics of Drosophila mating behavior

Mackay

Heinsohn

Lyman

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

132

134

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The first steps of animal speciation are thought to be the development of sexual isolating mechanisms. In contrast to recent progress in understanding the genetic basis of postzygotic isolating mechanisms, little is known about the genetic architecture of sexual isolation. Here, we have subjected Drosophila melanogaster to 29 generations of replicated divergent artificial selection for mating speed. The phenotypic response to selection was highly asymmetrical in the direction of reduced mating speed, with estimates of realized heritability averaging 7%. The selection response was largely attributable to a reduction in female receptivity. We assessed the whole genome transcriptional response to selection for mating speed using Affymetrix GeneChips and a rigorous statistical analysis. Remarkably, >3,700 probe sets (21% of the array elements) exhibited a divergence in message levels between the Fast and Slow replicate lines. Genes with altered transcriptional abundance in response to selection fell into many different biological process and molecular function Gene Ontology categories, indicating substantial pleiotropy for this complex behavior. Future functional studies are necessary to test the extent to which transcript profiling of divergent selection lines accurately predicts genes that directly affect the selected trait.Species are groups of actually or potentially interbreeding natural populations, which are reproductively isolated from other such groups.Recent studies by the students of animal behavior, as well as the revised interpretation of many earlier observations, indicate that behavior differences are among animals the most important factor in restricting random mating between closely related forms.E. Mayr, 1942

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“…The Fast and Slow replicate lines were significantly diverged from Generation 25. We analyzed the mating speed data from generations [25][26][27][28][29] …”

Section: Resultsmentioning

confidence: 99%

Section: Drosophila Mating Behaviormentioning

confidence: 99%

Genetics and genomics of Drosophila mating behavior

Mackay

Heinsohn

Lyman

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

132

134

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“…Similarly, agonists could be designed that couple the DopR99B receptor to one or another of the two second messenger pathways that it potentially can activate. Such compounds could lead to the development of highly effective insect control agents, given the preferential expression of this Drosophila dopamine receptor in mushroom bodies (Han et al, 1996) and the likely involvement of dopamine in the processes of learning and memory in the insect nervous system (Tempel et al, 1984;Budnik and White, 1988;Schafer and Rehder, 1989;Buchner, 1991;Nassel and Elekes, 1992). Further, genetic studies on dopamine receptor mutants in Drosophila could identify the physiological roles of the separate activation of each of the two second messenger systems potentially coupled to the DopR99B receptor, because a variation in the local G-protein environment of different cell types expressing this receptor might allow the receptor to be coupled differently in different cell types.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence also is accumulating for an important role for dopamine in learning and memory and in neuronal development in insects (Tempel et al, 1984;Budnik and White, 1988;Budnik et al, 1989;Buchner, 1991). However, very little information is available on dopamine receptors and their modes of action in insects.…”

Section: Abstract: Cloned Dopamine Receptor; Drosophila Melanogastermentioning

confidence: 99%

Agonist-Specific Coupling of a ClonedDrosophila melanogasterD1-Like Dopamine Receptor to Multiple Second Messenger Pathways by Synthetic Agonists

et al. 1997

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The mechanism of coupling of a cloned Drosophila D1-like dopamine receptor, DopR99B, to multiple second messenger systems when expressed in Xenopus oocytes is described. The receptor is coupled directly to the generation of a rapid, transient intracellular Ca 2ϩ signal, monitored as changes in inward current mediated by the oocyte endogenous Ca 2ϩ -activated chloride channel, by a pertussis toxin-insensitive G-proteincoupled pathway. The more prolonged receptor-mediated changes in adenylyl cyclase activity are generated by an independent G-protein-coupled pathway that is pertussis toxinsensitive but calcium-independent, and G ␤␥ -subunits appear to be involved in the transduction of this response. This is the first evidence for the direct coupling of a cloned D1-like dopamine receptor both to the activation of adenylyl cyclase and to the initiation of an intracellular Ca 2ϩ signal. The pharmacological profile of both second messenger effects is identical for a range of naturally occurring catecholamine ligands (dopamine Ͼ norepinephrine Ͼ epinephrine) and for the blockade of dopamine responses by a range of synthetic antagonists. However, the pharmacological profiles of the two second messenger responses differ for a range of synthetic agonists. Thus, the receptor exhibits agonist-specific coupling to second messenger systems for synthetic agonists. This feature could provide a useful tool in the genetic analysis of the roles of the multiple second messenger pathways activated by this receptor, given the likely involvement of dopamine in the processes of learning and memory in the insect nervous system.

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“…D. melanogaster provides an excellent system for mutational genetic and molecular analysis of neuroactive molecules (reviewed by Restifo and White, 1990;Buchner, 1991). Two D. melanogaster mutations, inactive and per, appear to affect octopamine metabolism (O'Dell et al, 1987;Livingstone and Tempel, 1983).…”

Section: Future Directionsmentioning

confidence: 99%

Octopamine immunoreactivity in the fruit fly Drosophila melanogaster

Monastirioti¹,

Gorczyca²,

Rapus³

et al. 1995

J of Comparative Neurology

184

170

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Octopamine has been proposed as a neurotransmitter/modulator/hormone serving a variety of physiological functions in invertebrates. We have initiated a study of octopamine in the fruit fly Drosophila melanogaster, which provides an excellent system for genetic and molecular analysis of neuroactive molecules. As a first step, the distribution of octopamine immunoreactivity was studied by means of an octopamine-specific antiserum. We focused on the central nervous system (CNS) and on the innervation of the larval body wall muscles. The larval octopamine neuronal pattern was composed of prominent neurons along the midline of the ventral ganglion, whereas brain lobes were devoid of immunoreactive somata. However, intense immunoreactive neuropil was observed both in the ventral ganglion and in the brain lobes. Some of the immunoreactive neurons sent peripheral fibers that innervated most of the muscles of the larval body wall. Octopamine immunoreactivity was observed at neuromuscular junctions in all larval stages, being present in a well-defined subset of synaptic boutons, type II. Octopamine immunoreactivity in the adult CNS revealed many additional neurons compared to the larval CNS, indicating that at least a subset of adult octopamine neurons may differentiate during metamorphosis. Major octopamineimmunoreactive neuronal clusters and neuronal processes were observed in the subesophageal ganglion, deutocerebrum, and dorsal protocerebrum, and intense neuropil staining was detected primarily in the optic lobes and in the central complex.Keywords octopamine neuron; insect nervous system; neuromuscular junction; synaptic bouton; immunocytochemistry Biogenic amines as chemical messengers in the nervous system of arthropods are thought to play crucial roles in several aspects of their behavior (reviewed by Bicker and Menzel, 1989). Octopamine, one of the biogenic amines extensively studied in invertebrates, has been proposed as neurotransmitter, neuromodulator, and neurohormone in a variety of physiological processes (for reviews, see David and Coulon, 1985;Evans, 1985Evans, , 1992 Address reprint requests to Dr. Maria Monastirioti, Department of Biology, Brandeis University, Waltham, MA 02254.. HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript Bicker and Menzel, 1989). In crustaceans, octopamine has been implicated in the neuromodulation of rapid response circuits controlling the escape behavior of crayfish (Glanzman and Krasne, 1983) and in the aggressive and submissive postures in lobsters (reviewed by Kravitz, 1988). In a variety of insect species, octopamine has been implicated in both central and peripheral neural functions. It stimulates activity of the firefly light organ (Nathanson, 1979), induces flight motor activity, and acts as neurotransmitter/modulator in the locust central nervous system (CNS; Sombati and Hoyle, 1984). Octopamine regulates hormone release in cockroaches (Downer et al., 1984), induces lipid and carbohydrate metabolism in crickets (Fields ...

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Genes Expressed in the Adult Brain ofDrosophilaand Effects of Their Mutations on Behavior: A Survey of Transmitter- and Second Messenger-Related Genes

Cited by 68 publications

References 270 publications

Genetics and genomics of Drosophila mating behavior

Genetics and genomics of Drosophila mating behavior

Agonist-Specific Coupling of a ClonedDrosophila melanogasterD1-Like Dopamine Receptor to Multiple Second Messenger Pathways by Synthetic Agonists

Octopamine immunoreactivity in the fruit fly Drosophila melanogaster

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