Genes differentially expressed with malignant transformation and metastatic tumor progression of murine squamous cell carcinoma

Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma

“…Thirdly, 5 (42%) of the immunopositive patients had developed metastases at the time of relapse, as against 4 (13%) of the immunonegative patients. This difference ( P = .035) extends previous in vitro findings showing a significant increase in Sp17 mRNA in 3 metastatic cell lines derived from the keratinocyte cell line Pam 212 after in vivo tumor progression [23]. The comparative analysis between Sp17 expression and the well-known markers of this rare neoplasia [1,19,20] has shown a statistically significant relation between Sp17 and chromogranin expression ( P = .014), whereas a nonsignificant relation was found between Sp17 expression and S-100, synaptophysin, and neurofilament markers (Table 3).…”

Increased levels of sperm protein 17 mRNA and circulating antibodies in periampullary carcinoma patients

“…It is primarily involved in the interaction of sperm with the zona pellucida of the oocyte during fertilization [5]. Dong et al reported the expression of Sp17 in malignant cells and suggested that it may play a role in cancer metastasis [6], although this role of Sp17 in cancer cells is yet to be elucidated. However, a research group reported the expression of Sp17 on ciliated cells [7].…”

Sperm Protein 17: Clinical Relevance of a Cancer/Testis Antigen, from Contraception to Cancer Immunotherapy, and Beyond

“…The first correlation between SP17 and cancer came from the study by Van Waes and colleagues [36], who found that SP17 expression was correlated with the metastatic potential of murine squamous cell carcinoma cell lines. In the same year, the group of Lea [37] identified specific anti-SP17 antibodies in the sera of vasectomized and Copyright C Informa Healthcare USA, Inc. Int Rev Immunol Downloaded from informahealthcare.com by Nyu Medical Center on 05/30/15 For personal use only.…”

“…Cloning and sequencing of human SP17 cDNA was first concluded in 1996 [35] and revealed the presence of two testis-specific cDNA of 1.3 and 1.6 kb. Each cDNA was shown to give rise to the same protein, and the predicted protein sequence displayed a high degree of homology with rabbit and mouse Sp17.The first correlation between SP17 and cancer came from the study by Van Waes and colleagues [36], who found that SP17 expression was correlated with the metastatic potential of murine squamous cell carcinoma cell lines. In the same year, the group of Lea [37] identified specific anti-SP17 antibodies in the sera of vasectomized and Copyright C Informa Healthcare USA, Inc. Int Rev Immunol Downloaded from informahealthcare.com by Nyu Medical Center on 05/30/15 For personal use only.…”