Genes controlling ovulation rate in sheep

Montgomery, G.

doi:10.1530/reprod/121.6.843

Cited by 17 publications

(30 citation statements)

References 17 publications

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“…Indeed a recent report shows that ALK5 (TGFβRI) is the type 1 receptor for GDF9 [19]. This finding suggests that GDF9 could have autocrine effects on the oocyte from the type 1 stage and paracrine effects on both the granulosa and theca cells from the type 4 (range [20]. S31 preantral) stage of growth.…”

Section: Intraovarian Sites Of Bmp15 and Gdf9 Gene Expression And Posmentioning

confidence: 96%

“…Q249R) in a highly conserved region of the intra cellular kinase domain [23,28,33]. The dominant phenotype is precocious ovarian follicular development [20] and exceptional prolificacy [4]. Some significant secondary effects have been observed in Booroola sheep, most likely because ALK6 mRNA is present in a wide range of tissues as well as the ovaries, including the brain, pituitary, kidneys, skeletal muscle, uterus and prostate and testes [20,33].…”

Section: The Alk6 (Bmpr-ib) Mutationmentioning

confidence: 99%

“…The dominant phenotype is precocious ovarian follicular development [20] and exceptional prolificacy [4]. Some significant secondary effects have been observed in Booroola sheep, most likely because ALK6 mRNA is present in a wide range of tissues as well as the ovaries, including the brain, pituitary, kidneys, skeletal muscle, uterus and prostate and testes [20,33]. ALK6 mRNA is also likely to be expressed in several tissues during fetal development such as the heart and mesonephros [17].…”

Section: The Alk6 (Bmpr-ib) Mutationmentioning

confidence: 99%

“…ALK6 mRNA is also likely to be expressed in several tissues during fetal development such as the heart and mesonephros [17]. The evidence for effects of the Q249R ALK6 mutation in various tissues during fetal development as well as on pituitary function and ovarian follicular formation have been summarised elsewhere [20]. As reported by Davis [4], the Booroola (Q249R ALK-6) mutation has now been identified in a number of different sheep breeds throughout the world.…”

Section: The Alk6 (Bmpr-ib) Mutationmentioning

confidence: 99%

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Physiological effects of major genes affecting ovulation rate in sheep

et al. 2005

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-Genetic mutations with major effects on ovulation rate in sheep were recently identified in two genes of the transforming growth factor (TGFβ) superfamily and a TGFβ receptor, namely bone morphogenetic protein 15 (BMP15), otherwise known as the growth differentiation factor 9b (GDF9b), GDF9 and activin-like kinase 6 (ALK6) otherwise known as the BMP receptor type IB (BMPRIB). Animals homozygous for the BMP15 or GDF9 mutations are anovulatory whereas animals heterozygous for BMP15 or GDF9 or heterozygous or homozygous for ALK6 have higher than normal ovulation rates. Immunisation of ewes against BMP15 or GDF9 shows that both are essential for normal follicular development and control of ovulation rate. Common features of fertile animals with the BMP15, ALK6 (and possibly GDF9) mutations are changes in oocyte development during early preantral follicular growth, earlier maturation of granulosa cells and ovulation of mature follicles at smaller diameters. In summary, these findings have led to a new paradigm in reproductive biology, namely that the oocyte plays a key role in regulating the ovulation rate. genetic mutations / BMP15 / GDF9 / ALK6 / BMPR-IB

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Section: Intraovarian Sites Of Bmp15 and Gdf9 Gene Expression And Posmentioning

confidence: 96%

Section: The Alk6 (Bmpr-ib) Mutationmentioning

confidence: 99%

Section: The Alk6 (Bmpr-ib) Mutationmentioning

confidence: 99%

Section: The Alk6 (Bmpr-ib) Mutationmentioning

confidence: 99%

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Physiological effects of major genes affecting ovulation rate in sheep

et al. 2005

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“…Correspondingly, breeding schemes for improved lamb-meat production have focused on selecting animals with superior reproductive capacities, and studies directed at the genetic improvement of sheep have been primarily concerned with reproductive traits (for review, see [45]). From a producer's standpoint, a greater number of lambs result in a higher profit margin.…”

Section: Introductionmentioning

confidence: 99%

The callipyge mutation and other genes that affect muscle hypertrophy in sheep

et al. 2005

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-Genetic strategies to improve the profitability of sheep operations have generally focused on traits for reproduction. However, natural mutations exist in sheep that affect muscle growth and development, and the exploitation of these mutations in breeding strategies has the potential to significantly improve lamb-meat quality. The best-documented mutation for muscle development in sheep is callipyge (CLPG), which causes a postnatal muscle hypertrophy that is localized to the pelvic limbs and loin. Enhanced skeletal muscle growth is also observed in animals with the Carwell (or rib-eye muscling) mutation, and a double-muscling phenotype has been documented for animals of the Texel sheep breed. However, the actual mutations responsible for these muscular hypertrophy phenotypes in sheep have yet to be identified, and further characterization of the genetic basis for these phenotypes will provide insight into the biological control of muscle growth and body composition.sheep / muscle / hypertrophy / callipyge / mutation

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Integration of proximate and evolutionary explanation of reproductive strategy: The case of callitrichid primates and implications for human biology

Tardif

Ross

2009

American J Hum Biol

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We offer examples of how proximate and evolutionary forms of argument may inform each other in better understanding reproductive strategy in callitrichid primates, the smallest of the anthropoid primates. In addition, we illustrate how comparative approaches, when applied judiciously, can aid in the formulation of hypotheses regarding even seemingly unique traits within a taxonomic group. In the first example, examination of the nature of genetics in cytokine systems that leads to altered ovulation number in sheep suggests some relatively simple changes could explain both the adaptation of increased ovulation number in marmosets and the subsequent decrease in ovulation number in the closely related species, callimico. In the second example, the role of body size and phylogeny in explaining the role of maternal energy constraints upon gestation and lactation is explored, leading to additional hypotheses regarding these relations in a species that is both small but also in a phylogenetic line selected for slow reproduction. Finally, the role of comparative data in the study of proximate and evolutionary explanations of "unique" human reproductive strategies is discussed.

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Genes controlling ovulation rate in sheep

Cited by 17 publications

References 17 publications

Physiological effects of major genes affecting ovulation rate in sheep

Physiological effects of major genes affecting ovulation rate in sheep

The callipyge mutation and other genes that affect muscle hypertrophy in sheep

Integration of proximate and evolutionary explanation of reproductive strategy: The case of callitrichid primates and implications for human biology

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