Genes conferring resistance to 8-aza adenine in Neurospora crassa and the variability of resistant alleles in the aza-l locus with respect to excretion of purines

Jha, K. K.

doi:10.1007/bf00332786

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1972

2001

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Cited by 4 publications

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An unlinked mutation affecting control of purine metabolism in a revertant of an ad-7 auxotroph of Neurospora crassa lacking the phosphoribosylpyrophosphate amidotransferase

Jha

1972

Molec. Gen. Genetics

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Prototrophic revertants of an ad-7 mutant recover phosphoribosylpyrophosphate amidotransferase activity, indicating ad-7 is the structural gene for the first enzyme in the de novo biosynthesis of purine nucleotides. Some revertants excrete purines and cross-feed ad-3A conidia which have a lesion in the de novo pathway. A mutant apu, not linked to ad-7 or ad-8, is responsible for the ability to excrete purines. This mutation is not allelic to a mutant in the aza-1 locus which is also known to excrete purines.

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An unlinked mutation affecting control of purine metabolism in a revertant of an ad-7 auxotroph of Neurospora crassa lacking the phosphoribosylpyrophosphate amidotransferase

Jha

1972

Molec. Gen. Genetics

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The location of the feedback-specific region within thePyrimidine-3 locus ofNeurospora crassa

Makoff

Radford

1976

Molec. Gen. Genet.

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The purimidine-3 locus of Neurospora crassa specifies two enzyme activities, pyrimidine-specific carbamyl phosphate synthetase (CPSpyr) and aspartate transcarbamylase (ATC). ATC is translationally distal. CPSpyr, but not ATC, is subject to feedback inhibition by uridine triphosphate (UTP). To investigate the location of the feedback-specific region within the locus, inhibition of a number of pyr-3 alleles by UTP was investigated. All CPS+ ATC- polar alleles, revertants of CPS- ATC- polar alleles, and 5-fluorouracil-resistant mutants had normal UTP response. The location of the feedback-specific region is in or close to the CPS-specific region.

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2001

The Neurospora Compendium

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Genes conferring resistance to 8-aza adenine in Neurospora crassa and the variability of resistant alleles in the aza-l locus with respect to excretion of purines

Cited by 4 publications

References 16 publications

An unlinked mutation affecting control of purine metabolism in a revertant of an ad-7 auxotroph of Neurospora crassa lacking the phosphoribosylpyrophosphate amidotransferase

An unlinked mutation affecting control of purine metabolism in a revertant of an ad-7 auxotroph of Neurospora crassa lacking the phosphoribosylpyrophosphate amidotransferase

The location of the feedback-specific region within thePyrimidine-3 locus ofNeurospora crassa

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