Genes and Hypertension

Dominiczak, Anna F.; Negrin, Domingo C.; Clark, James S.; Brosnan, M J; McBride, Martin W.; Alexander, M

doi:10.1161/01.hyp.35.1.164

Cited by 91 publications

(38 citation statements)

References 94 publications

(88 reference statements)

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“…EH is likely to be a polygenic disorder that results from the inheritance of a number of susceptibility genes. The causal genes identified probably contribute to between 30% and 50% of the variation in blood pressure seen among individuals (1). These genetic determinants interact with environmental factors such as dietary salt to produce the final disease phenotype.…”

Section: Introductionmentioning

confidence: 99%

Haplotype-Based Case-Control Study Revealing an Association between the Adrenomedullin Gene and Proteinuria in Subjects with Essential Hypertension

et al. 2005

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Section: Introductionmentioning

confidence: 99%

Haplotype-Based Case-Control Study Revealing an Association between the Adrenomedullin Gene and Proteinuria in Subjects with Essential Hypertension

et al. 2005

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“…Attempts to identify multiple genes, each with a small contribution to the common polygenic form of hypertension, have been less successful. 12,13 Many association as well as linkage studies of humans have provided useful, although somewhat contradictory, data. This showed the complexities of this disorder.…”

Section: Discussionmentioning

confidence: 99%

Linkage analysis of five candidate genes and essential hypertension in 106 Chinese nuclear families

Wang

Huang

et al. 2003

J Hum Hypertens

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Five candidate genes including the lipoprotein lipase, leptin, leptin receptor, a-adducin and b3 adrenergic receptor were selected to examine their possible contribution to essential hypertension (EH) in a Chinese population. On each side of the candidate gene loci, one to two highly polymorphic microsatellite markers were genotyped in 474 subjects recruited from 106 hypertension nuclear families in Shanghai. Both parametric and nonparametric linkage analyses were carried out using GENEHUNTER (version 2.0) after genotyping. Extended transmission disequilibrium testing (ETDT) was also conducted to detect preferential transmission of alleles to affected offspring. We failed to find the linkage between all these loci and EH by either parametric or nonparametric analysis, nor did we detect any significant transmission disequilibrium by ETDT. Our findings provide no support for a significant contribution of these five genes to the pathogenesis of EH among Shanghai people.

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“…Specifically, genetic factors can influence blood pressure elevation by 30-50%. 2 Thus, over the last decade, many genetic studies have aimed to clarify the causal genes of hypertension, as reviewed previously. 3 Genetic research on hypertension started using the candidate gene approach by investigating renin-angiotensin system (RAS)-related genes.…”

Section: Introductionmentioning

confidence: 99%

Pharmacogenomic approaches to study the effects of antihypertensive drugs

2012

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Pharmacogenomic studies aim to clarify the role of various genes and their variations in relation to the effects of antihypertensive drugs to establish a personalized pharmacotherapeutic treatment based on a patient's genetic background. Until recently, there have been numerous pharmacogenetic/pharmacogenomic studies on antihypertensive drugs using candidate genes, but only a few genome-wide approaches have been completed. In this review article, we discuss current trends and future directions of pharmacogenomic studies on antihypertensive drugs. Hypertension Research (2012) 35, 796-799; doi:10.1038/hr.2012; published online 28 June 2012 Keywords: antihypertensive drugs; candidate genes; GWAS; pharmacogenomics; tailored medicine INTRODUCTION Hypertension is the most common risk factor for atherosclerotic cardiovascular diseases, and its morbidity is greater than 50% in subjects aged 65 years and older in Japan and most Western countries. In Japan, the number of patients with hypertension is estimated to be greater than 40 million. 1 Hypertension is a multifactorial disease in which genetic and environmental factors are closely related. Specifically, genetic factors can influence blood pressure elevation by 30-50%. 2 Thus, over the last decade, many genetic studies have aimed to clarify the causal genes of hypertension, as reviewed previously. 3 Genetic research on hypertension started using the candidate gene approach by investigating renin-angiotensin system (RAS)-related genes. [4][5][6] Recently, several large-scale genome-wide association studies (GWASs) for hypertension 7-9 were performed, and B50 single nucleotide polymorphisms (SNPs) were identified as possible causal genes.The goal of genetic studies on hypertension is mainly to clarify the causal genes of hypertension and the mechanisms of blood pressure elevation. Consequently, these approaches may lead to the production of novel antihypertensive drugs. Another important aim is to establish personalized pharmacotherapy based on genetic information. These were the two main aims of the Japanese Millennium Project for Hypertension. 10 As mentioned, the first aim may be reasonably addressed by large-scale GWAS, but the second aim has not yet been examined in the field of hypertension research.Recent studies indicate that the heterogeneity of patients' responses to antihypertensive treatment is, at least in part, genetically determined. 11 This finding underscores the role of pharmacogenetic/ pharmacogenomic research in identifying either functional genetic variations or those variations inherited by linkage disequili-

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Genes and Hypertension

Cited by 91 publications

References 94 publications

Haplotype-Based Case-Control Study Revealing an Association between the Adrenomedullin Gene and Proteinuria in Subjects with Essential Hypertension

Haplotype-Based Case-Control Study Revealing an Association between the Adrenomedullin Gene and Proteinuria in Subjects with Essential Hypertension

Linkage analysis of five candidate genes and essential hypertension in 106 Chinese nuclear families

Pharmacogenomic approaches to study the effects of antihypertensive drugs

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