Generic physiologically based kinetic modelling for farm animals: Part I. Data collection of physiological parameters in swine, cattle and sheep

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part I: Cattle and swine

“…The present study fills many data gaps in the recently published review article on physiological parameters in cattle, swine, and sheep (Lautz, Dorne, et al, 2019). For example, in the study by Lautz, Dorne, et al (2019), many parameter values are not available, such as physiological parameters in calves, blood flows in the kidney and reproductive organs (i.e., testes, uterus, and ovaries) in beef cattle and dairy cows, as well as vascular space or volume fraction of blood in organs (i.e., % organ weight) in cattle and swine. These parameters were tabulated in the present manuscript.…”

“…When selecting physiological parameter values to use in a PBPK model, it is important to consider whether the parameter value is biologically plausible and whether it is consistent with values reported in existing literature. Overall, compared to the mini‐review by Lautz, Dorne, et al (2019), the present study provides a comprehensive database on PBPK‐related physiological parameters in cattle and swine in the context of their potential application to food animal safety endpoints, as well as providing a detailed discussion on the validity of the parameter values reported.…”

“…As a result, it is difficult to evaluate the validity of their parameter values. For example, the blood flows to the liver as a fraction of cardiac output are 24.6% and 66.0% in beef cattle and dairy cattle, respectively, in Lautz, Dorne, et al (2019). Since these two values are both for adult animals in the same species and the major difference is lactating vs. nonlactating, this large difference is hard to interpret biologically.…”

“…These parameters were tabulated in the present manuscript. In Lautz, Dorne, et al (2019), physiological parameter values are presented, but without discussion on the consistency with values reported in existing PBPK models. As a result, it is difficult to evaluate the validity of their parameter values.…”

“…The focus of this article is on the principles, methodology and existing applications of PBPK models, thus the physiological values are primarily based on previously published PBPK models, rather than based on original experimental studies. A recent mini‐review on physiological parameters in swine, cattle, and sheep has been published (Lautz, Dorne, Oldenkamp, Hendriks, & Ragas, 2019). However, this study does not consider different production classes (i.e., calves vs. adult beef cattle vs. dairy cows) or breed differences, and the values of multiple parameters are not available.…”