Generic Conditions for Electromembrane Extraction of Acids with Low to Moderate Hydrophilicity in Human Plasma
Chenchen Song,
Samira Dowlatshah,
Somayeh Gaznawi
et al.
Abstract:The current paper reports the first set of generic conditions for electromembrane extraction of acidic substances from human plasma. Two systems were developed, based on eutectic solvents; A1 (“A” for acid) comprised dodecyl methyl sulfoxide and thymol in 1:2 ratio (w/w) as liquid membrane, while A2 used [6-methylcoumarin:thymol (1:2)]:2-nitrophenyl octyl ether in 2:1 ratio (w/w). A1 and A2 were applied for extraction of 31 acidic model analytes spiked into 100 µL human plasma diluted 1:1 (v/v) with phosphate … Show more
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