Generic and Disease-Specific Measures of Quality of Life in Patients with Mild Alzheimer’s Disease

Bhattacharya, Suvosree; Vogel, Asmus; Hansen, Martin Hangaard; Waldorff, Frans Boch; Waldemar, Gunhild

doi:10.1159/000320588

Cited by 30 publications

(31 citation statements)

References 56 publications

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“…The association between increased depressive symptoms and reduced QOL is well established in LOD, as most studies show this to be a significant factor across dementia severity and type of residency [28-35]. Neuropsychiatric symptoms (NPS) are also important predictors in community-dwelling and institutionalized people with LOD, especially in proxy-reported QOL [19, 31, 36-38].…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia

Hvidsten

Engedal

Selbæk

et al. 2018

Dement Geriatr Cogn Disord

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Aims: The aims of this study were to compare quality of life (QOL) in people with young-onset Alzheimer’s (AD) and frontotemporal (FTD) dementia, explore variables associated with QOL, and compare QOL in young-onset dementia (YOD) and late-onset dementia (LOD). Methods: Cross-sectional data from a Nordic multicenter study of 50 community-dwelling participants with AD and 38 with FTD were included. A comparison group consisted of 100 people with LOD. QOL was measured using self-reported Euro-QOL 5-Dimension and the proxy version of Quality of Life in Alzheimer’s Disease (QOL-AD) questionnaire. Neuropsychiatric symptoms and needs were assessed using the Cornell Scale for Depression in Dementia (CSDD), Neuropsychiatric Inventory (NPI), and Camberwell Assessment of Needs in the Elderly. Multiple linear regression and multilevel modeling was used to determine variables associated with QOL. Results: We found no differences between the two YOD groups in QOL. The variables associated with QOL were scores on the CSDD, NPI, and unmet needs. The proxy QOL-AD score in YOD was significantly higher compared to LOD (median 36.0 [IQR 10.0] vs. 33.0 [IQR 9.0]). Conclusion: The QOL in Nordic people with YOD was better compared to people with LOD. Our results show depressive symptoms to be associated with QOL irrespective of age and diagnosis.

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Section: Introductionmentioning

confidence: 99%

Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia

Hvidsten

Engedal

Selbæk

et al. 2018

Dement Geriatr Cogn Disord

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“…However, in this study there was no significant effect of the DAISY intervention on any quality of life measure. Based on results in a previous report29 we found that proxy rated quality of life probably better reflects progression of clinical measures as compared to patient-rated measures, and that EQ-5D is a suitable alternative to disease-specific quality of life measures in research. Additionally, it was assumed that the average trend between the observation points was linear.…”

Section: Discussionmentioning

confidence: 80%

Early psychosocial intervention in Alzheimer's disease: cost utility evaluation alongside the Danish Alzheimer's Intervention Study (DAISY)

et al. 2014

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ObjectiveTo assess the cost utility of early psychosocial intervention for patients with Alzheimer's disease and their primary caregivers.DesignCost utility evaluation alongside a multicentre, randomised controlled trial with 3 years of follow-up.SettingPrimary care and memory clinics in five Danish districts.Participants330 community-dwelling patients and their primary caregivers.InterventionPsychosocial counselling and support lasting 8–12 months after diagnosis and follow-up at 3, 6, 12 and 36 months in the intervention group or follow-up only in the control group.Main outcome measuresThe primary outcome measure was the cost of additional quality-adjusted life years (QALYs). Costs were measured from a societal perspective, including the costs of healthcare, social care, informal care and production loss. QALYs were estimated separately for the patient and the caregiver before aggregation for the main analysis.ResultsNone of the observed cost and QALY measures were significantly different between the intervention and control groups, although a tendency was noted for psychosocial care leading to cost increases with informal care that was not outweighed by the tendency for cost savings with formal care. The probability of psychosocial intervention being cost-effective did not exceed 36% for any threshold value. The alternative scenario analysis showed that the probability of cost-effectiveness increased over the range of threshold values used if the cost perspective was restricted to formal healthcare.ConclusionsA multifaceted, psychosocial intervention programme was found unlikely to be cost-effective from a societal perspective. The recommendation for practice in settings that are similar to the Danish setting is to provide follow-up with referral to available local support programmes when needed, and to restrict large multifaceted intervention programmes to patients and caregivers with special needs until further evidence for cost-effectiveness emerges.Trial registrationThe study was registered in the Clinical Trial Database as ISRCTN74848736.

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“…However, we found that the majority of the QOL research has been conducted among caregivers rather than people suffering from AD themselves. On the other hand, previous longitudinal studies monitoring self-rated QOL in AD patients in the early stages (mild to moderate stages) have demonstrated not only better reliability and validity but also not much inter-rater differences compared to caregiver-rated QOL [53][54][55][56][57][58][59][60][61][62][63]. As a result, further research about the reliability and validity of QOL assessment for individuals with AD is required.…”

Section: Discussionmentioning

confidence: 99%

Global Mapping of Interventions to Improve Quality of Life of Patients with Alzheimer’s Disease during 1990–2018

Hoang¹,

Ha²,

Pham³

et al. 2019

Dement Geriatr Cogn Disord

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Background: Alzheimer's disease (AD) with its high burden on disability is known as one of the critical public health issues worldwide. Hence, providing comprehensive care and effective symptomatic treatment are becoming a challenge for many healthcare systems. Quality of life (QOL) has been identified as an important indicator to develop holistic care for people living with AD since it reflects treatment response, the progression of AD, and activities of daily living. This study aimed to identify research trends and landscapes as well as important factors in QOL studies in the field of AD. Summary: English research was extracted from the online database Web of Science to analyze research publications' growth rate and content on AD and QOL. VOSviewer was used to visualize the correlations between terms in titles and abstracts. Research topics were created using Latent Dirichlet Allocation of abstracts' content and disciplines. Major landscapes in the QOL assessment included care and treatment for AD in epidemiological studies and clinical trials. Besides, most studies were conducted in highincome countries, such as the USA or the United Kingdom. Findings of our study also identi-fied a lack of contextualized factors and research gaps in terms of QOL among individuals with AD. Key Messages: Further studies should be conducted taking an effort to assess QOL among demented patients as well as advancing knowledge, attitude, and practice among family caregivers. diagnosis to reduce depression, agitation, and anxiety caused by the disorder, as well as behavioral issues, such as delusions, that can accompany AD.Some limitations should be acknowledged. The search was conducted via the WOS, and only English reviews and articles were included. However, there is a high possibility that a large number of papers for analysis are indexed in other databases, including PubMed and Scopus. Hence, our results should not be generalized to all types of publications. Further studies might be available to conduct a systematic review and meta-analysis of how QOL can shed light on the effect of treatment or interventions regarding AD. ConclusionUsing scientometric analysis, the global academic trends and interest concerning QOL and AD have been illustrated. By using LDA, our results highlighted that QOL of caregivers has received attention from scientists. Further longitudinal studies are required to identify empirical evidence for developing new interventions for AD, assessing QOL in patients with AD as well as improving knowledge and support for caregivers.

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Generic and Disease-Specific Measures of Quality of Life in Patients with Mild Alzheimer’s Disease

Cited by 30 publications

References 56 publications

Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia

Quality of Life in People with Young-Onset Alzheimer’s Dementia and Frontotemporal Dementia

Early psychosocial intervention in Alzheimer's disease: cost utility evaluation alongside the Danish Alzheimer's Intervention Study (DAISY)

Global Mapping of Interventions to Improve Quality of Life of Patients with Alzheimer’s Disease during 1990–2018

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