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ABSTRACT
2Although the trend in radionuclide generator research has declined (FIG. 1 ), radionuclide generator systems continue to play an important role in nuclear medicine [l-31. obtained from the molybdenum-99/technetium-99m generator system is used in over 80 per cent of all diagnostic clinical studies and there is increasing interest and use of therapeutic radioisotopes obtained from generator systems. This paper focuses on a discussion of the major current areas of radionuclide generator research, and the expected areas of future research and applications.
1.The Molydenum-99/Technetium-99rn GeneratorThe easiest and preferred route for obtaining technetium-99m for radiopharmaceutical "kit" labeling is via elution of the chromatographic-type molybdenum-99/technetium-99m generator.Because technetium-99mis expected to continue to be the primary radioisotope used for imaging in diagnostic clinical nuclear medicine, the availability of molybdenum-99 is crucial to the radiopharmaceutical and clinical communities. In the more developed countries, fission-produced molybdenum-99 for is used for fabrication of the chromatographic-type molybdenum-99/technetium-99m generator [4]. Although until recently only one site provided most of the fission-produced molybdenum-99 for generator fabrication in North America, there are currently several new sites throughout the world producing this important radioisotope ( Table 1). Wit...