2010
DOI: 10.4049/jimmunol.1000060
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Generation of Th1-Polarizing Dendritic Cells Using the TLR7/8 Agonist CL075

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Cited by 72 publications
(74 citation statements)
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References 50 publications
(62 reference statements)
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“…4,31,32 Our results reveal significantly lower in vivo and in vitro amounts of pro-inflammatory cytokines in the Lt.shTLR7-injected joints and Lt.shTLR7-transduced CIASFs, respectively. Furthermore, i.a.…”
Section: Discussionmentioning
confidence: 75%
See 1 more Smart Citation
“…4,31,32 Our results reveal significantly lower in vivo and in vitro amounts of pro-inflammatory cytokines in the Lt.shTLR7-injected joints and Lt.shTLR7-transduced CIASFs, respectively. Furthermore, i.a.…”
Section: Discussionmentioning
confidence: 75%
“…1 -3 Notably, the Th1-and Th17-mediated immune responses can be initiated or augmented through the ligation of TLRs with their ligands. 4,5 However, strong TLR-induced responses might contribute to the induction of autoimmunity and lead to lethal systemic inflammation. 6 Animal experiments have documented the ability of TLR ligands in triggering the onset of arthritis.…”
Section: Introductionmentioning
confidence: 99%
“…[50][51][52][53][54] We currently test the clinical use of DCs generated with a 3D protocol, based on a collaboration with Prof. Schendel and collegues. 55 This protocol includes a TLR seven out of eight agonist that enhance the IL-12 secretion of the DCs and their ability to generate Th1-like responses in vitro and in mouse models. 56 Of note, it remains to be seen if this or other modifications yield the desired effect in cancer patients.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, DC vaccines are an alternative approach for cell-based immunotherapy (1)(2)(3)(4)(5). DCs generally have been derived from peripheral mononuclear cells of human blood or spleen or bone marrow in animal models (6)(7)(8), and different methods can be used for loading them. Despite a large number of DC vaccine studies, only one study was approved by the Food and Drug Administration (FDA), which consists of not only DCs but also other antigen presenting cells (9).…”
Section: Introductionmentioning
confidence: 99%